CATH Domain 1fieB03

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.60	Sandwich
	2.60.40	Immunoglobulin-like
	2.60.40.10	Immunoglobulins

Domain Context

CATH Clusters

Superfamily	Immunoglobulins
Functional Family	protein-glutamine gamma-glutamyltransferase 6

Enzyme Information

2.3.2.13

Protein-glutamine gamma-glutamyltransferase.

based on mapping to UniProt P00488

A protein-L-glutamine + a protein-L-lysine = a protein with an N(6)- (gamma-glutamyl)-L-lysine cross-link + NH(3).

-!- The gamma-carboxymide groups of peptide-bound glutamine residues act as acyl donors, and the 6-amino-groups of protein- and peptide-bound lysine residues act as acceptors, to give intra- and inter-molecular N(6)-(5-glutamyl)lysine cross-links.

UniProtKB Entries (1)

P00488

F13A_HUMAN

Homo sapiens

Coagulation factor XIII A chain

PDB Structure

PDB	1FIE
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Saccharomyces
Primary Citation	Structural evidence that the activation peptide is not released upon thrombin cleavage of factor XIII. Yee, V.C., Pedersen, L.C., Bishop, P.D., Stenkamp, R.E., Teller, D.C. Thromb.Res.