CATH Domain 1ezvE01

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.20	Up-down Bundle
	1.20.5	Single alpha-helices involved in coiled-coils or other helix-helix interfaces
	1.20.5.270	Ubiquinol cytochrome reductase, transmembrane domain

Domain Context

CATH Clusters

Superfamily	Ubiquinol cytochrome reductase, transmembrane domain
Functional Family	Cytochrome b-c1 complex subunit Rieske, mitochondrial

Enzyme Information

7.1.1.8

Quinol--cytochrome-c reductase.

based on mapping to UniProt P08067

Quinol + 2 ferricytochrome c(Side 2) = quinone + 2 ferrocytochrome c(Side 2) + 2 H(+)(Side 2).

-!- The enzyme, often referred to as the cytochrome bc1 complex or complex III, is the third complex in the electron transport chain. -!- It is present in the mitochondria of all aerobic eukaryotes and in the inner membranes of most bacteria. -!- The mammalian enzyme contains cytochromes b-562, b-566 and c(1), and a 2-iron ferredoxin. -!- Depending on the organism and physiological conditions, the enzyme extrudes either two or four protons from the cytoplasmic to the non- cytoplasmic compartment (cf. EC 1.6.99.3). -!- Formerly EC 1.10.2.2.

UniProtKB Entries (2)

P18531	HVM60_MOUSE Mus musculus Ig heavy chain V region 3-6
P08525	QCR8_YEAST Saccharomyces cerevisiae S288C Cytochrome b-c1 complex subunit 8

PDB Structure

PDB	1EZV
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Structure at 2.3 A resolution of the cytochrome bc(1) complex from the yeast Saccharomyces cerevisiae co-crystallized with an antibody Fv fragment. Hunte, C., Koepke, J., Lange, C., Rossmanith, T., Michel, H. Structure Fold.Des.