×

Network disruptions

We have been experiencing disruptions on our local network which has affected the stability of these web pages. We have been working with IT support team to get this fixed as a matter of urgency and apologise for any inconvenience.

CATH Classification

Domain Context

CATH Clusters

Superfamily Eco RI Endonuclease, subunit A
Functional Family

Enzyme Information

3.1.21.4
Type II site-specific deoxyribonuclease.
based on mapping to UniProt P00642
Endonucleolytic cleavage of DNA to give specific double-stranded fragments with terminal 5'-phosphates.
-!- Large group of enzymes which recognize specific short DNA sequences and cleave either within, or at a short specific distance from, the recognition site. -!- See the REBASE database for a complete list of these enzymes: http://rebase.neb.com/rebase/

UniProtKB Entries (1)

P00642
T2E1_ECOLX
Escherichia coli
Type-2 restriction enzyme EcoRI

PDB Structure

PDB 1ERI
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Refinement of Eco RI endonuclease crystal structure: a revised protein chain tracing.
Kim, Y.C., Grable, J.C., Love, R., Greene, P.J., Rosenberg, J.M.
Science
CATH-Gene3D is a Global Biodata Core Resource Learn more...