CATH Domain 1e1xA02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.510	Transferase(Phosphotransferase); domain 1
	1.10.510.10	Transferase(Phosphotransferase) domain 1

Domain Context

CATH Clusters

Superfamily	Transferase(Phosphotransferase) domain 1
Functional Family	Cyclin-dependent kinase 2

Enzyme Information

2.7.11.22

Cyclin-dependent kinase.

based on mapping to UniProt P24941

ATP + a protein = ADP + a phosphoprotein.

-!- Activation of cyclin-dependent kinases requires association of the enzyme with a regulatory subunit referred to as a cyclin. -!- It is the sequential activation and inactivation of cyclin-dependent kinases, through the periodic synthesis and destruction of cyclins, that provides the primary means of cell-cycle regulation. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

P24941

CDK2_HUMAN

Homo sapiens

Cyclin-dependent kinase 2

PDB Structure

PDB	1E1X
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Identification of Novel Purine and Pyrimidine Cyclin-Dependent Kinase Inhibitors with Distinct Molecular Interactions and Tumor Cell Growth Inhibition Profiles. Arris, C.E., Boyle, F.T., Calvert, A.H., Curtin, N.J., Endicott, J.A., Garman, E.F., Gibson, A.E., Golding, B.T., Grant, S., Griffin, R.J., Jewsbury, P., Johnson, L.N., Lawrie, A.M., Newell, D.R., Noble, M.E.M., Sausville, E.A., Schultz, R., Yu, W. J.Med.Chem.