CATH Domain 1dsuA01

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.10	Thrombin, subunit H
	2.40.10.10	Trypsin-like serine proteases

Domain Context

CATH Clusters

Superfamily	Trypsin-like serine proteases
Functional Family	Complement factor D

Enzyme Information

3.4.21.46

Complement factor D.

based on mapping to UniProt P00746

Selective cleavage of Arg-|-Lys bond in complement factor B when in complex with complement subcomponent C3b or with cobra venom factor.

-!- A component of the alternative pathway of complement activation. -!- This reaction is analogous to the activation of complement component C2 by activated complement subcomponent C1s. -!- Belongs to peptidase family S1.

UniProtKB Entries (1)

P00746

CFAD_HUMAN

Homo sapiens

Complement factor D

PDB Structure

PDB	1DSU
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structure of human factor D. A complement system protein at 2.0 A resolution. Narayana, S.V., Carson, M., el-Kabbani, O., Kilpatrick, J.M., Moore, D., Chen, X., Bugg, C.E., Volanakis, J.E., DeLucas, L.J. J.Mol.Biol.