CATH Domain 1dqyA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.1820	alpha/beta hydrolase

Domain Context

CATH Clusters

Superfamily	alpha/beta hydrolase
Functional Family	Diacylglycerol acyltransferase/mycolyltransferase Ag85C

Enzyme Information

2.3.1.122	Trehalose O-mycolyltransferase. based on mapping to UniProt P9WQN9 2 alpha,alpha'-trehalose 6-mycolate = alpha,alpha'-trehalose + alpha,alpha'-trehalose 6,6'-bismycolate. -!- Catalyzes the exchange of mycolic acid between trehalose, trehalose mycolate and trehalose bismycolate. -!- Trehalose 6-palmitate can also act as donor.
2.3.1.20	Diacylglycerol O-acyltransferase. based on mapping to UniProt P9WQN9 Acyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerol. -!- Palmitoyl-CoA and other long-chain acyl-CoAs can act as donors.

UniProtKB Entries (1)

A85C_MYCTU

Mycobacterium tuberculosis H37Rv

Diacylglycerol acyltransferase/mycolyltransferase Ag85C

PDB Structure

PDB	1DQY
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Crystal structure of the secreted form of antigen 85C reveals potential targets for mycobacterial drugs and vaccines. Ronning, D.R., Klabunde, T., Besra, G.S., Vissa, V.D., Belisle, J.T., Sacchettini, J.C. Nat.Struct.Biol.