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1 keywords

CATH Domain 1c6yB00

CATH Classification

Level CATH Code Description
Class 2 Mainly Beta
Architecture 2.40 Beta Barrel
Topology 2.40.70 Cathepsin D, subunit A; domain 1
Homologous Superfamily 2.40.70.10 Acid Proteases

Domain Context

CATH Clusters

Superfamily Acid Proteases
Functional Family Gag-Pol polyprotein

Enzyme Information

UniProtKB Entries (1)

O09893
O09893_9HIV1
Human immunodeficiency virus 1
Protease

PDB Structure

PDB 1C6Y
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
An alternate binding site for the P1-P3 group of a class of potent HIV-1 protease inhibitors as a result of concerted structural change in the 80s loop of the protease.
Munshi, S., Chen, Z., Yan, Y., Li, Y., Olsen, D.B., Schock, H.B., Galvin, B.B., Dorsey, B., Kuo, L.C.
Acta Crystallogr.,Sect.D
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