CATH Domain 1brcE02

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CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.10	Thrombin, subunit H
	2.40.10.10	Trypsin-like serine proteases

Domain Context

CATH Clusters

Superfamily	Trypsin-like serine proteases
Functional Family	Anionic trypsin

Enzyme Information

3.4.21.4

Trypsin.

based on mapping to UniProt P00763

Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.

-!- Belongs to peptidase family S1. -!- Formerly EC 3.4.4.4.

UniProtKB Entries (2)

P00763	TRY2_RAT Rattus norvegicus Anionic trypsin-2
P05067	A4_HUMAN Homo sapiens Amyloid-beta precursor protein

PDB Structure

PDB	1BRC
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Relocating a negative charge in the binding pocket of trypsin. Perona, J.J., Tsu, C.A., McGrath, M.E., Craik, C.S., Fletterick, R.J. J.Mol.Biol.