CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.62 | Nef Regulatory Factor |
|
3.30.62.10 | Nef Regulatory Factor |
Domain Context
CATH Clusters
| Superfamily | Nef Regulatory Factor |
| Functional Family | Protein Nef |
Enzyme Information
UniProtKB Entries (2)
| P03406 |
NEF_HV1BR
Human immunodeficiency virus type 1 (BRU ISOLATE)
Protein Nef
|
| P06241 |
FYN_HUMAN
Homo sapiens
Tyrosine-protein kinase Fyn
|
PDB Structure
| PDB | 1AVZ |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
The crystal structure of HIV-1 Nef protein bound to the Fyn kinase SH3 domain suggests a role for this complex in altered T cell receptor signaling.
Structure
|
