CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.40 | Beta Barrel |
|
2.40.10 | Thrombin, subunit H |
|
2.40.10.10 | Trypsin-like serine proteases |
Domain Context
CATH Clusters
| Superfamily | Trypsin-like serine proteases |
| Functional Family | Tissue-type plasminogen activator |
Enzyme Information
| 3.4.21.68 |
T-plasminogen activator.
based on mapping to UniProt P98119
Specific cleavage of Arg-|-Val bond in plasminogen to form plasmin.
-!- From a wide variety of mammalian tissues, especially endothelial cells. -!- Secreted as a single chain precursor which is cleaved to a two-chain form by plasmin. -!- Activity is considerably enhanced by fibrin. -!- Belongs to peptidase family S1. -!- Formerly EC 3.4.21.31 and EC 3.4.99.26.
|
UniProtKB Entries (1)
| P98119 |
URT1_DESRO
Desmodus rotundus
Salivary plasminogen activator alpha 1
|
PDB Structure
| PDB | 1A5I |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Mesocricetus |
| Primary Citation |
Catalytic domain structure of vampire bat plasminogen activator: a molecular paradigm for proteolysis without activation cleavage.
Biochemistry
|
