The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"PHR domain
".
2.60.120.820
superfamily
Functional Families
Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
Superfamily: PHR domain
This superfamily includes the PHR domain which was first found in Pam, Highwire and RPM-1 proteins, that it is named after. PHR proteins are conserved, large multi-domain E3 ubiquitin ligases with modular architecture. PHR proteins presynaptically control synaptic growth and axon guidance and postsynaptically regulate endocytosis of glutamate receptors. Dysfunction of neuronal ubiquitin-mediated proteasomal degradation is implicated in various neurodegenerative diseases. PHR proteins are characterised by the presence of two PHR domains near the N-terminus, which are essential for proper localisation and function. The domain has a beta-sandwich fold composed of 11 anti-parallel beta-strands.
The C-terminal region of the protein BTBD1 includes the PHR domain and is known to interact with Topoisomerase I, an enzyme which relaxes DNA supercoils.
PFAM:PF08005, INTERPRO:IPR012983,DOI:10.1016/j.jmb.2010.02.017
GO Diversity
Unique GO annotations
79 Unique GO terms
EC Diversity
Unique EC annotations
0 Unique EC terms
Species Diversity
Unique species annotations
463 Unique species
Sequence/Structure Diversity
Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.
Superfamily Summary
A general summary of information for this superfamily.
| Structures | |
|---|---|
| Domains: | 5 |
| Domain clusters (>95% seq id): | 3 |
| Domain clusters (>35% seq id): | 3 |
| Unique PDBs: | 3 |
| Alignments | |
| Structural Clusters (5A): | 1 |
| Structural Clusters (9A): | 1 |
| FunFam Clusters: | 25 |
| Function | |
| Unique EC: | |
| Unique GO: | 79 |
| Taxonomy | |
| Unique Species: | 463 |
