Identification of CNS-Penetrant Aryl Sulfonamides as Isoform-Selective NaV1.6 Inhibitors with Efficacy in Mouse Models of Epilepsy.
Focken, T., Burford, K., Grimwood, M.E., Zenova, A., Andrez, J.C., Gong, W., Wilson, M., Taron, M., Decker, S., Lofstrand, V., Chowdhury, S., Shuart, N., Lin, S., Goodchild, S.J., Young, C., Soriano, M., Tari, P.K., Waldbrook, M., Nelkenbrecher, K., Kwan, R., Lindgren, A., de Boer, G., Lee, S., Sojo, L., DeVita, R.J., Cohen, C.J., Wesolowski, S.S., Johnson Jr., J.P., Dehnhardt, C.M., Empfield, J.R.
J.Med.Chem.