PDB Information

PDB6R5F
MethodX-RAY DIFFRACTION
Host OrganismBaculovirus expression vector pFastBac1-HM
Gene SourceHomo sapiens
Primary Citation
Discovery and Lead-Optimization of 4,5-Dihydropyrazoles as Mono-Kinase Selective, Orally Bioavailable and Efficacious Inhibitors of Receptor Interacting Protein 1 (RIP1) Kinase.
Harris, P.A., Faucher, N., George, N., Eidam, P.M., King, B.W., White, G.V., Anderson, N.A., Bandyopadhyay, D., Beal, A.M., Beneton, V., Berger, S.B., Campobasso, N., Campos, S., Capriotti, C.A., Cox, J.A., Daugan, A., Donche, F., Fouchet, M.H., Finger, J.N., Geddes, B., Gough, P.J., Grondin, P., Hoffman, B.L., Hoffman, S.J., Hutchinson, S.E., Jeong, J.U., Jigorel, E., Lamoureux, P., Leister, L.K., Lich, J.D., Mahajan, M.K., Meslamani, J., Mosley, J.E., Nagilla, R., Nassau, P.M., Ng, S.L., Ouellette, M.T., Pasikanti, K.K., Potvain, F., Reilly, M.A., Rivera, E.J., Sautet, S., Schaeffer, M.C., Sehon, C.A., Sun, H., Thorpe, J.H., Totoritis, R.D., Ward, P., Wellaway, N., Wisnoski, D.D., Woolven, J.M., Bertin, J., Marquis, R.W.
J.Med.Chem.
HeaderTransferase
Released2019-03-25
Resolution3.250
CATH Insert Date05 May, 2019

PDB Images (13)

PDB Prints

PDB Chains (4)

Chain ID Date inserted into CATH CATH Status
A 05 May, 2019 Chopped
B 05 May, 2019 Chopped
C 05 May, 2019 Chopped
D 05 May, 2019 Chopped

CATH Domains (8)

Domain ID Date inserted into CATH Superfamily CATH Status
6r5fA01 06 May, 2019 3.30.200.20 Assigned
6r5fA02 06 May, 2019 1.10.510.10 Assigned
6r5fB01 06 May, 2019 3.30.200.20 Assigned
6r5fB02 06 May, 2019 1.10.510.10 Assigned
6r5fC01 06 May, 2019 3.30.200.20 Assigned
6r5fC02 06 May, 2019 1.10.510.10 Assigned
6r5fD01 06 May, 2019 3.30.200.20 Assigned
6r5fD02 06 May, 2019 1.10.510.10 Assigned

UniProtKB Entries (4)

Accession Gene ID Taxon Description
Q13546 RIPK1_HUMAN Homo sapiens Receptor-interacting serine/threonine-protein kinase 1
Q13546 RIPK1_HUMAN Homo sapiens Receptor-interacting serine/threonine-protein kinase 1
Q13546 RIPK1_HUMAN Homo sapiens Receptor-interacting serine/threonine-protein kinase 1
Q13546 RIPK1_HUMAN Homo sapiens Receptor-interacting serine/threonine-protein kinase 1