PDB 6qm8

PDB Links
Overview

PDB Information

PDB	6QM8
Method	ELECTRON MICROSCOPY
Host Organism
Gene Source
Primary Citation	Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition. Wyllie, S., Brand, S., Thomas, M., De Rycker, M., Chung, C.W., Pena, I., Bingham, R.P., Bueren-Calabuig, J.A., Cantizani, J., Cebrian, D., Craggs, P.D., Ferguson, L., Goswami, P., Hobrath, J., Howe, J., Jeacock, L., Ko, E.J., Korczynska, J., MacLean, L., Manthri, S., Martinez, M.S., Mata-Cantero, L., Moniz, S., Nuhs, A., Osuna-Cabello, M., Pinto, E., Riley, J., Robinson, S., Rowland, P., Simeons, F.R.C., Shishikura, Y., Spinks, D., Stojanovski, L., Thomas, J., Thompson, S., Viayna Gaza, E., Wall, R.J., Zuccotto, F., Horn, D., Ferguson, M.A.J., Fairlamb, A.H., Fiandor, J.M., Martin, J., Gray, D.W., Miles, T.J., Gilbert, I.H., Read, K.D., Marco, M., Wyatt, P.G. Proc.Natl.Acad.Sci.USA
Header	Hydrolase
Released	2019-02-01
Resolution	3.300
CATH Insert Date	21 Apr, 2019

PDB Images (49)

6qm8

PDB 6qm8

6qm8a

PDB Chain 6qm8a

6qm8A

PDB Chain 6qm8A

6qm8b

PDB Chain 6qm8b

6qm8B

PDB Chain 6qm8B

6qm8C

PDB Chain 6qm8C

6qm8D

PDB Chain 6qm8D

6qm8E

PDB Chain 6qm8E

6qm8F

PDB Chain 6qm8F

6qm8G

PDB Chain 6qm8G

6qm8H

PDB Chain 6qm8H

6qm8I

PDB Chain 6qm8I

6qm8J

PDB Chain 6qm8J

6qm8K

PDB Chain 6qm8K

6qm8L

PDB Chain 6qm8L

6qm8M

PDB Chain 6qm8M

6qm8N

PDB Chain 6qm8N

6qm8O

PDB Chain 6qm8O

6qm8P

PDB Chain 6qm8P

6qm8Q

PDB Chain 6qm8Q

6qm8R

PDB Chain 6qm8R

6qm8S

PDB Chain 6qm8S

6qm8T

PDB Chain 6qm8T

6qm8U

PDB Chain 6qm8U

6qm8V

PDB Chain 6qm8V

6qm8W

PDB Chain 6qm8W

6qm8X

PDB Chain 6qm8X

6qm8Y

PDB Chain 6qm8Y

6qm8Z

PDB Chain 6qm8Z

6qm8a00

CATH Domain 6qm8a00

6qm8A00

CATH Domain 6qm8A00

6qm8b00

CATH Domain 6qm8b00

6qm8D00

CATH Domain 6qm8D00

6qm8F00

CATH Domain 6qm8F00

6qm8G00

CATH Domain 6qm8G00

6qm8I00

CATH Domain 6qm8I00

6qm8J00

CATH Domain 6qm8J00

6qm8K00

CATH Domain 6qm8K00

6qm8L00

CATH Domain 6qm8L00

6qm8M00

CATH Domain 6qm8M00

6qm8N00

CATH Domain 6qm8N00

6qm8O00

CATH Domain 6qm8O00

6qm8R00

CATH Domain 6qm8R00

6qm8T00

CATH Domain 6qm8T00

6qm8U00

CATH Domain 6qm8U00

6qm8W00

CATH Domain 6qm8W00

6qm8X00

CATH Domain 6qm8X00

6qm8Y00

CATH Domain 6qm8Y00

6qm8Z00

CATH Domain 6qm8Z00

PDB Prints

PDB Chains (28)

Chain ID	Date inserted into CATH	CATH Status
a	21 Apr, 2019	Chopped
A	21 Apr, 2019	Chopped
b	21 Apr, 2019	Chopped
B	21 Apr, 2019	Holding pen
C	21 Apr, 2019	Holding pen
D	21 Apr, 2019	Chopped
E	21 Apr, 2019	Holding pen
F	21 Apr, 2019	Chopped
G	21 Apr, 2019	Chopped
H	21 Apr, 2019	Holding pen
I	21 Apr, 2019	Chopped
J	21 Apr, 2019	Chopped
K	21 Apr, 2019	Chopped
L	21 Apr, 2019	Chopped
M	21 Apr, 2019	Chopped
N	21 Apr, 2019	Chopped
O	21 Apr, 2019	Chopped
P	21 Apr, 2019	Holding pen
Q	21 Apr, 2019	Ballcock
R	21 Apr, 2019	Chopped
S	21 Apr, 2019	Holding pen
T	21 Apr, 2019	Chopped
U	21 Apr, 2019	Chopped
V	21 Apr, 2019	Ballcock
W	21 Apr, 2019	Chopped
X	21 Apr, 2019	Chopped
Y	21 Apr, 2019	Chopped
Z	21 Apr, 2019	Chopped

CATH Domains (20)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
6qm8a00	22 Apr, 2019	3.60.20.10	Assigned
6qm8A00	22 Apr, 2019	3.60.20.10	Assigned
6qm8b00	22 Apr, 2019	3.60.20.10	Assigned
6qm8D00	22 Apr, 2019	3.60.20.10	Assigned
6qm8F00	22 Apr, 2019	3.60.20.10	Assigned
6qm8G00	22 Apr, 2019	3.60.20.10	Assigned
6qm8I00	22 Apr, 2019	3.60.20.10	Assigned
6qm8J00	22 Apr, 2019	3.60.20.10	Assigned
6qm8K00	22 Apr, 2019	3.60.20.10	Assigned
6qm8L00	22 Apr, 2019	3.60.20.10	Assigned
6qm8M00	22 Apr, 2019	3.60.20.10	Assigned
6qm8N00	22 Apr, 2019	3.60.20.10	Assigned
6qm8O00	22 Apr, 2019	3.60.20.10	Assigned
6qm8R00	22 Apr, 2019	3.60.20.10	Assigned
6qm8T00	22 Apr, 2019	3.60.20.10	Assigned
6qm8U00	22 Apr, 2019	3.60.20.10	Assigned
6qm8W00	22 Apr, 2019	3.60.20.10	Assigned
6qm8X00	22 Apr, 2019	3.60.20.10	Assigned
6qm8Y00	22 Apr, 2019	3.60.20.10	Assigned
6qm8Z00	22 Apr, 2019	3.60.20.10	Assigned

UniProtKB Entries (28)

Accession	Gene ID	Taxon	Description
Q9GNZ8	Q9GNZ8_LEIIN	Leishmania infantum	Proteasome subunit alpha type
Q7JMX2	Q7JMX2_LEIIN	Leishmania infantum	Proteasome subunit alpha type
A0A381MU64	A0A381MU64_LEIIN	Leishmania infantum	Proteasome subunit beta
A4HVX3	A4HVX3_LEIIN	Leishmania infantum	Proteasome subunit alpha type
Q9GNZ8	Q9GNZ8_LEIIN	Leishmania infantum	Proteasome subunit alpha type
A4I357	A4I357_LEIIN	Leishmania infantum	Proteasome endopeptidase complex
A4IBS2	A4IBS2_LEIIN	Leishmania infantum	Proteasome subunit beta
Q7JMX2	Q7JMX2_LEIIN	Leishmania infantum	Proteasome subunit alpha type
A4HUT6	A4HUT6_LEIIN	Leishmania infantum	Proteasome subunit alpha type
A4HV47	A4HV47_LEIIN	Leishmania infantum	Proteasome subunit beta
A4IDD6	A4IDD6_LEIIN	Leishmania infantum	Proteasome subunit beta
A4HZI9	A4HZI9_LEIIN	Leishmania infantum	Proteasome subunit alpha type
A4ICV5	A4ICV5_LEIIN	Leishmania infantum	Proteasome subunit beta
A4IDD0	A4IDD0_LEIIN	Leishmania infantum	Proteasome subunit alpha type
A4I384	A4I384_LEIIN	Leishmania infantum	Proteasome subunit beta
A4ICV5	A4ICV5_LEIIN	Leishmania infantum	Proteasome subunit beta
A4HV47	A4HV47_LEIIN	Leishmania infantum	Proteasome subunit beta
A4I357	A4I357_LEIIN	Leishmania infantum	Proteasome endopeptidase complex
A4I384	A4I384_LEIIN	Leishmania infantum	Proteasome subunit beta
A4IBS2	A4IBS2_LEIIN	Leishmania infantum	Proteasome subunit beta
A0A381MU64	A0A381MU64_LEIIN	Leishmania infantum	Proteasome subunit beta
A4HSQ5	A4HSQ5_LEIIN	Leishmania infantum	Proteasome subunit beta
A4HZI9	A4HZI9_LEIIN	Leishmania infantum	Proteasome subunit alpha type
A4IDD0	A4IDD0_LEIIN	Leishmania infantum	Proteasome subunit alpha type
A4HSQ5	A4HSQ5_LEIIN	Leishmania infantum	Proteasome subunit beta
A4IDD6	A4IDD6_LEIIN	Leishmania infantum	Proteasome subunit beta
A4HVX3	A4HVX3_LEIIN	Leishmania infantum	Proteasome subunit alpha type
A4HUT6	A4HUT6_LEIIN	Leishmania infantum	Proteasome subunit alpha type