PDB 6pgo

PDB Information

PDB6PGO
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli BL21(DE3)
Gene SourceHomo sapiens
Primary Citation
Discovery of a covalent inhibitor of KRASG12C (AMG 510) for the treatment of solid tumors.
Lanman, B.A., Allen, J.R., Allen, J.G., Amegadzie, A.K., Ashton, K.S., Booker, S.K., Chen, J.J., Chen, N., Frohn, M.J., Goodman, G., Kopecky, D.J., Liu, L., Lopez, P., Low, J.D., Ma, V., Minatti, A.E., Nguyen, T.T., Nishimura, N., Pickrell, A.J., Reed, A.B., Shin, Y., Siegmund, A., Tamayo, N.A., Tegley, C.M., Walton, M.C., Wang, H.L., Wurz, R.P., Xue, M., Yang, K.C., Achanta, P., Bartberger, M.D., Canon, J., Hollis, L.S., McCarter, J.D., Mohr, C., Rex, K., Saiki, A.Y., San Miguel, T., Volak, L., Wang, K.H., Whittington, D.A., Zech, S.G., Lipford, J.R., Cee, V.J.
J.Med.Chem.
HeaderSignaling Protein/Inhibitor
Released2019-06-24
Resolution1.600
CATH Insert Date29 Dec, 2019

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PDB Chains (0)

Chain ID Date inserted into CATH CATH Status

CATH Domains (0)

Domain ID Date inserted into CATH Superfamily CATH Status

UniProtKB Entries (0)

Accession Gene ID Taxon Description