PDB 6hwd

PDB Links
Overview

PDB Information

PDB	6HWD
Method	X-RAY DIFFRACTION
Host Organism	Saccharomyces cerevisiae S288c
Gene Source	Saccharomyces cerevisiae S288c
Primary Citation	Structure-Based Design of Inhibitors Selective for Human Proteasome beta 2c or beta 2i Subunits. Xin, B.T., Huber, E.M., de Bruin, G., Heinemeyer, W., Maurits, E., Espinal, C., Du, Y., Janssens, M., Weyburne, E.S., Kisselev, A.F., Florea, B.I., Driessen, C., van der Marel, G.A., Groll, M., Overkleeft, H.S. J.Med.Chem.
Header	Hydrolase
Released	2018-10-11
Resolution	2.800
CATH Insert Date	03 Feb, 2019

PDB Images (57)

6hwd

PDB 6hwd

6hwda

PDB Chain 6hwda

6hwdA

PDB Chain 6hwdA

6hwdb

PDB Chain 6hwdb

6hwdB

PDB Chain 6hwdB

6hwdC

PDB Chain 6hwdC

6hwdD

PDB Chain 6hwdD

6hwdE

PDB Chain 6hwdE

6hwdF

PDB Chain 6hwdF

6hwdG

PDB Chain 6hwdG

6hwdH

PDB Chain 6hwdH

6hwdI

PDB Chain 6hwdI

6hwdJ

PDB Chain 6hwdJ

6hwdK

PDB Chain 6hwdK

6hwdL

PDB Chain 6hwdL

6hwdM

PDB Chain 6hwdM

6hwdN

PDB Chain 6hwdN

6hwdO

PDB Chain 6hwdO

6hwdP

PDB Chain 6hwdP

6hwdQ

PDB Chain 6hwdQ

6hwdR

PDB Chain 6hwdR

6hwdS

PDB Chain 6hwdS

6hwdT

PDB Chain 6hwdT

6hwdU

PDB Chain 6hwdU

6hwdV

PDB Chain 6hwdV

6hwdW

PDB Chain 6hwdW

6hwdX

PDB Chain 6hwdX

6hwdY

PDB Chain 6hwdY

6hwdZ

PDB Chain 6hwdZ

6hwda00

CATH Domain 6hwda00

6hwdA00

CATH Domain 6hwdA00

6hwdb00

CATH Domain 6hwdb00

6hwdB00

CATH Domain 6hwdB00

6hwdC00

CATH Domain 6hwdC00

6hwdD00

CATH Domain 6hwdD00

6hwdE00

CATH Domain 6hwdE00

6hwdF00

CATH Domain 6hwdF00

6hwdG00

CATH Domain 6hwdG00

6hwdH00

CATH Domain 6hwdH00

6hwdI00

CATH Domain 6hwdI00

6hwdJ00

CATH Domain 6hwdJ00

6hwdK00

CATH Domain 6hwdK00

6hwdL00

CATH Domain 6hwdL00

6hwdM00

CATH Domain 6hwdM00

6hwdN00

CATH Domain 6hwdN00

6hwdO00

CATH Domain 6hwdO00

6hwdP00

CATH Domain 6hwdP00

6hwdQ00

CATH Domain 6hwdQ00

6hwdR00

CATH Domain 6hwdR00

6hwdS00

CATH Domain 6hwdS00

6hwdT00

CATH Domain 6hwdT00

6hwdU00

CATH Domain 6hwdU00

6hwdV00

CATH Domain 6hwdV00

6hwdW00

CATH Domain 6hwdW00

6hwdX00

CATH Domain 6hwdX00

6hwdY00

CATH Domain 6hwdY00

6hwdZ00

CATH Domain 6hwdZ00

PDB Prints

PDB Chains (28)

Chain ID	Date inserted into CATH	CATH Status
a	03 Feb, 2019	Chopped
A	03 Feb, 2019	Chopped
b	03 Feb, 2019	Chopped
B	03 Feb, 2019	Chopped
C	03 Feb, 2019	Chopped
D	03 Feb, 2019	Chopped
E	03 Feb, 2019	Chopped
F	03 Feb, 2019	Chopped
G	03 Feb, 2019	Chopped
H	03 Feb, 2019	Chopped
I	03 Feb, 2019	Chopped
J	03 Feb, 2019	Chopped
K	03 Feb, 2019	Chopped
L	03 Feb, 2019	Chopped
M	03 Feb, 2019	Chopped
N	03 Feb, 2019	Chopped
O	03 Feb, 2019	Chopped
P	03 Feb, 2019	Chopped
Q	03 Feb, 2019	Chopped
R	03 Feb, 2019	Chopped
S	03 Feb, 2019	Chopped
T	03 Feb, 2019	Chopped
U	03 Feb, 2019	Chopped
V	03 Feb, 2019	Chopped
W	03 Feb, 2019	Chopped
X	03 Feb, 2019	Chopped
Y	03 Feb, 2019	Chopped
Z	03 Feb, 2019	Chopped

CATH Domains (28)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
6hwda00	04 Feb, 2019	3.60.20.10	Assigned
6hwdA00	04 Feb, 2019	3.60.20.10	Assigned
6hwdb00	04 Feb, 2019	3.60.20.10	Assigned
6hwdB00	04 Feb, 2019	3.60.20.10	Assigned
6hwdC00	04 Feb, 2019	3.60.20.10	Assigned
6hwdD00	04 Feb, 2019	3.60.20.10	Assigned
6hwdE00	04 Feb, 2019	3.60.20.10	Assigned
6hwdF00	04 Feb, 2019	3.60.20.10	Assigned
6hwdG00	04 Feb, 2019	3.60.20.10	Assigned
6hwdH00	04 Feb, 2019	3.60.20.10	Assigned
6hwdI00	04 Feb, 2019	3.60.20.10	Assigned
6hwdJ00	04 Feb, 2019	3.60.20.10	Assigned
6hwdK00	04 Feb, 2019	3.60.20.10	Assigned
6hwdL00	04 Feb, 2019	3.60.20.10	Assigned
6hwdM00	04 Feb, 2019	3.60.20.10	Assigned
6hwdN00	04 Feb, 2019	3.60.20.10	Assigned
6hwdO00	04 Feb, 2019	3.60.20.10	Assigned
6hwdP00	04 Feb, 2019	3.60.20.10	Assigned
6hwdQ00	04 Feb, 2019	3.60.20.10	Assigned
6hwdR00	04 Feb, 2019	3.60.20.10	Assigned
6hwdS00	04 Feb, 2019	3.60.20.10	Assigned
6hwdT00	04 Feb, 2019	3.60.20.10	Assigned
6hwdU00	04 Feb, 2019	3.60.20.10	Assigned
6hwdV00	04 Feb, 2019	3.60.20.10	Assigned
6hwdW00	04 Feb, 2019	3.60.20.10	Assigned
6hwdX00	04 Feb, 2019	3.60.20.10	Assigned
6hwdY00	04 Feb, 2019	3.60.20.10	Assigned
6hwdZ00	04 Feb, 2019	3.60.20.10	Assigned

UniProtKB Entries (28)

Accession	Gene ID	Taxon	Description
P40303	PSA4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-4
P40302	PSA6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-6
P30657	PSB7_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-7
P30656	PSB5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-5
P38624	PSB1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-1
P25043	PSB2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-2
P21243	PSA1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-1
P21242	PSA7_YEAST	Saccharomyces cerevisiae S288C	Probable proteasome subunit alpha type-7
P32379	PSA5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-5
P40303	PSA4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-4
P25043	PSB2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-2
P21242	PSA7_YEAST	Saccharomyces cerevisiae S288C	Probable proteasome subunit alpha type-7
P23639	PSA2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-2
P23638	PSA3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-3
P25451	PSB3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-3
P23724	PSB6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-6
P23639	PSA2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-2
P25451	PSB3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-3
P22141	PSB4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-4
P32379	PSA5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-5
P23724	PSB6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-6
P22141	PSB4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-4
P23638	PSA3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-3
P30656	PSB5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-5
P38624	PSB1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-1
P40302	PSA6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-6
P21243	PSA1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-1
P30657	PSB7_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-7