PDB 6hwa

PDB Links
Overview

PDB Information

PDB	6HWA
Method	X-RAY DIFFRACTION
Host Organism
Gene Source
Primary Citation	Structure-Based Design of Inhibitors Selective for Human Proteasome beta 2c or beta 2i Subunits. Xin, B.T., Huber, E.M., de Bruin, G., Heinemeyer, W., Maurits, E., Espinal, C., Du, Y., Janssens, M., Weyburne, E.S., Kisselev, A.F., Florea, B.I., Driessen, C., van der Marel, G.A., Groll, M., Overkleeft, H.S. J.Med.Chem.
Header	Hydrolase
Released	2018-10-11
Resolution	2.800
CATH Insert Date	03 Feb, 2019

PDB Images (57)

6hwa

PDB 6hwa

6hwaa

PDB Chain 6hwaa

6hwaA

PDB Chain 6hwaA

6hwab

PDB Chain 6hwab

6hwaB

PDB Chain 6hwaB

6hwaC

PDB Chain 6hwaC

6hwaD

PDB Chain 6hwaD

6hwaE

PDB Chain 6hwaE

6hwaF

PDB Chain 6hwaF

6hwaG

PDB Chain 6hwaG

6hwaH

PDB Chain 6hwaH

6hwaI

PDB Chain 6hwaI

6hwaJ

PDB Chain 6hwaJ

6hwaK

PDB Chain 6hwaK

6hwaL

PDB Chain 6hwaL

6hwaM

PDB Chain 6hwaM

6hwaN

PDB Chain 6hwaN

6hwaO

PDB Chain 6hwaO

6hwaP

PDB Chain 6hwaP

6hwaQ

PDB Chain 6hwaQ

6hwaR

PDB Chain 6hwaR

6hwaS

PDB Chain 6hwaS

6hwaT

PDB Chain 6hwaT

6hwaU

PDB Chain 6hwaU

6hwaV

PDB Chain 6hwaV

6hwaW

PDB Chain 6hwaW

6hwaX

PDB Chain 6hwaX

6hwaY

PDB Chain 6hwaY

6hwaZ

PDB Chain 6hwaZ

6hwaa00

CATH Domain 6hwaa00

6hwaA00

CATH Domain 6hwaA00

6hwab00

CATH Domain 6hwab00

6hwaB00

CATH Domain 6hwaB00

6hwaC00

CATH Domain 6hwaC00

6hwaD00

CATH Domain 6hwaD00

6hwaE00

CATH Domain 6hwaE00

6hwaF00

CATH Domain 6hwaF00

6hwaG00

CATH Domain 6hwaG00

6hwaH00

CATH Domain 6hwaH00

6hwaI00

CATH Domain 6hwaI00

6hwaJ00

CATH Domain 6hwaJ00

6hwaK00

CATH Domain 6hwaK00

6hwaL00

CATH Domain 6hwaL00

6hwaM00

CATH Domain 6hwaM00

6hwaN00

CATH Domain 6hwaN00

6hwaO00

CATH Domain 6hwaO00

6hwaP00

CATH Domain 6hwaP00

6hwaQ00

CATH Domain 6hwaQ00

6hwaR00

CATH Domain 6hwaR00

6hwaS00

CATH Domain 6hwaS00

6hwaT00

CATH Domain 6hwaT00

6hwaU00

CATH Domain 6hwaU00

6hwaV00

CATH Domain 6hwaV00

6hwaW00

CATH Domain 6hwaW00

6hwaX00

CATH Domain 6hwaX00

6hwaY00

CATH Domain 6hwaY00

6hwaZ00

CATH Domain 6hwaZ00

PDB Prints

PDB Chains (28)

Chain ID	Date inserted into CATH	CATH Status
a	03 Feb, 2019	Chopped
A	03 Feb, 2019	Chopped
b	03 Feb, 2019	Chopped
B	03 Feb, 2019	Chopped
C	03 Feb, 2019	Chopped
D	03 Feb, 2019	Chopped
E	03 Feb, 2019	Chopped
F	03 Feb, 2019	Chopped
G	03 Feb, 2019	Chopped
H	03 Feb, 2019	Chopped
I	03 Feb, 2019	Chopped
J	03 Feb, 2019	Chopped
K	03 Feb, 2019	Chopped
L	03 Feb, 2019	Chopped
M	03 Feb, 2019	Chopped
N	03 Feb, 2019	Chopped
O	03 Feb, 2019	Chopped
P	03 Feb, 2019	Chopped
Q	03 Feb, 2019	Chopped
R	03 Feb, 2019	Chopped
S	03 Feb, 2019	Chopped
T	03 Feb, 2019	Chopped
U	03 Feb, 2019	Chopped
V	03 Feb, 2019	Chopped
W	03 Feb, 2019	Chopped
X	03 Feb, 2019	Chopped
Y	03 Feb, 2019	Chopped
Z	03 Feb, 2019	Chopped

CATH Domains (28)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
6hwaa00	04 Feb, 2019	3.60.20.10	Assigned
6hwaA00	04 Feb, 2019	3.60.20.10	Assigned
6hwab00	04 Feb, 2019	3.60.20.10	Assigned
6hwaB00	04 Feb, 2019	3.60.20.10	Assigned
6hwaC00	04 Feb, 2019	3.60.20.10	Assigned
6hwaD00	04 Feb, 2019	3.60.20.10	Assigned
6hwaE00	04 Feb, 2019	3.60.20.10	Assigned
6hwaF00	04 Feb, 2019	3.60.20.10	Assigned
6hwaG00	04 Feb, 2019	3.60.20.10	Assigned
6hwaH00	04 Feb, 2019	3.60.20.10	Assigned
6hwaI00	04 Feb, 2019	3.60.20.10	Assigned
6hwaJ00	04 Feb, 2019	3.60.20.10	Assigned
6hwaK00	04 Feb, 2019	3.60.20.10	Assigned
6hwaL00	04 Feb, 2019	3.60.20.10	Assigned
6hwaM00	04 Feb, 2019	3.60.20.10	Assigned
6hwaN00	04 Feb, 2019	3.60.20.10	Assigned
6hwaO00	04 Feb, 2019	3.60.20.10	Assigned
6hwaP00	04 Feb, 2019	3.60.20.10	Assigned
6hwaQ00	04 Feb, 2019	3.60.20.10	Assigned
6hwaR00	04 Feb, 2019	3.60.20.10	Assigned
6hwaS00	04 Feb, 2019	3.60.20.10	Assigned
6hwaT00	04 Feb, 2019	3.60.20.10	Assigned
6hwaU00	04 Feb, 2019	3.60.20.10	Assigned
6hwaV00	04 Feb, 2019	3.60.20.10	Assigned
6hwaW00	04 Feb, 2019	3.60.20.10	Assigned
6hwaX00	04 Feb, 2019	3.60.20.10	Assigned
6hwaY00	04 Feb, 2019	3.60.20.10	Assigned
6hwaZ00	04 Feb, 2019	3.60.20.10	Assigned

UniProtKB Entries (28)

Accession	Gene ID	Taxon	Description
P23639	PSA2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-2
P23724	PSB6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-6
P38624	PSB1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-1
P23638	PSA3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-3
P21243	PSA1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-1
P38624	PSB1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-1
P40303	PSA4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-4
P23724	PSB6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-6
P21243	PSA1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-1
P30657	PSB7_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-7
P30656	PSB5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-5
P30656	PSB5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-5
P32379	PSA5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-5
P23639	PSA2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-2
P40302	PSA6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-6
P25451	PSB3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-3
P40302	PSA6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-6
P40303	PSA4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-4
P25043	PSB2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-2
P23638	PSA3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-3
P25451	PSB3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-3
P30657	PSB7_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-7
P22141	PSB4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-4
P25043	PSB2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-2
P21242	PSA7_YEAST	Saccharomyces cerevisiae S288C	Probable proteasome subunit alpha type-7
P21242	PSA7_YEAST	Saccharomyces cerevisiae S288C	Probable proteasome subunit alpha type-7
P22141	PSB4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-4
P32379	PSA5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-5