PDB 6hw5

PDB Links
Overview

PDB Information

PDB	6HW5
Method	X-RAY DIFFRACTION
Host Organism
Gene Source
Primary Citation	Structure-Based Design of Inhibitors Selective for Human Proteasome beta 2c or beta 2i Subunits. Xin, B.T., Huber, E.M., de Bruin, G., Heinemeyer, W., Maurits, E., Espinal, C., Du, Y., Janssens, M., Weyburne, E.S., Kisselev, A.F., Florea, B.I., Driessen, C., van der Marel, G.A., Groll, M., Overkleeft, H.S. J.Med.Chem.
Header	Hydrolase
Released	2018-10-11
Resolution	2.900
CATH Insert Date	03 Feb, 2019

PDB Images (57)

6hw5

PDB 6hw5

6hw5a

PDB Chain 6hw5a

6hw5A

PDB Chain 6hw5A

6hw5b

PDB Chain 6hw5b

6hw5B

PDB Chain 6hw5B

6hw5C

PDB Chain 6hw5C

6hw5D

PDB Chain 6hw5D

6hw5E

PDB Chain 6hw5E

6hw5F

PDB Chain 6hw5F

6hw5G

PDB Chain 6hw5G

6hw5H

PDB Chain 6hw5H

6hw5I

PDB Chain 6hw5I

6hw5J

PDB Chain 6hw5J

6hw5K

PDB Chain 6hw5K

6hw5L

PDB Chain 6hw5L

6hw5M

PDB Chain 6hw5M

6hw5N

PDB Chain 6hw5N

6hw5O

PDB Chain 6hw5O

6hw5P

PDB Chain 6hw5P

6hw5Q

PDB Chain 6hw5Q

6hw5R

PDB Chain 6hw5R

6hw5S

PDB Chain 6hw5S

6hw5T

PDB Chain 6hw5T

6hw5U

PDB Chain 6hw5U

6hw5V

PDB Chain 6hw5V

6hw5W

PDB Chain 6hw5W

6hw5X

PDB Chain 6hw5X

6hw5Y

PDB Chain 6hw5Y

6hw5Z

PDB Chain 6hw5Z

6hw5a00

CATH Domain 6hw5a00

6hw5A00

CATH Domain 6hw5A00

6hw5b00

CATH Domain 6hw5b00

6hw5B00

CATH Domain 6hw5B00

6hw5C00

CATH Domain 6hw5C00

6hw5D00

CATH Domain 6hw5D00

6hw5E00

CATH Domain 6hw5E00

6hw5F00

CATH Domain 6hw5F00

6hw5G00

CATH Domain 6hw5G00

6hw5H00

CATH Domain 6hw5H00

6hw5I00

CATH Domain 6hw5I00

6hw5J00

CATH Domain 6hw5J00

6hw5K00

CATH Domain 6hw5K00

6hw5L00

CATH Domain 6hw5L00

6hw5M00

CATH Domain 6hw5M00

6hw5N00

CATH Domain 6hw5N00

6hw5O00

CATH Domain 6hw5O00

6hw5P00

CATH Domain 6hw5P00

6hw5Q00

CATH Domain 6hw5Q00

6hw5R00

CATH Domain 6hw5R00

6hw5S00

CATH Domain 6hw5S00

6hw5T00

CATH Domain 6hw5T00

6hw5U00

CATH Domain 6hw5U00

6hw5V00

CATH Domain 6hw5V00

6hw5W00

CATH Domain 6hw5W00

6hw5X00

CATH Domain 6hw5X00

6hw5Y00

CATH Domain 6hw5Y00

6hw5Z00

CATH Domain 6hw5Z00

PDB Prints

PDB Chains (28)

Chain ID	Date inserted into CATH	CATH Status
a	03 Feb, 2019	Chopped
A	03 Feb, 2019	Chopped
b	03 Feb, 2019	Chopped
B	03 Feb, 2019	Chopped
C	03 Feb, 2019	Chopped
D	03 Feb, 2019	Chopped
E	03 Feb, 2019	Chopped
F	03 Feb, 2019	Chopped
G	03 Feb, 2019	Chopped
H	03 Feb, 2019	Chopped
I	03 Feb, 2019	Chopped
J	03 Feb, 2019	Chopped
K	03 Feb, 2019	Chopped
L	03 Feb, 2019	Chopped
M	03 Feb, 2019	Chopped
N	03 Feb, 2019	Chopped
O	03 Feb, 2019	Chopped
P	03 Feb, 2019	Chopped
Q	03 Feb, 2019	Chopped
R	03 Feb, 2019	Chopped
S	03 Feb, 2019	Chopped
T	03 Feb, 2019	Chopped
U	03 Feb, 2019	Chopped
V	03 Feb, 2019	Chopped
W	03 Feb, 2019	Chopped
X	03 Feb, 2019	Chopped
Y	03 Feb, 2019	Chopped
Z	03 Feb, 2019	Chopped

CATH Domains (28)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
6hw5a00	04 Feb, 2019	3.60.20.10	Assigned
6hw5A00	04 Feb, 2019	3.60.20.10	Assigned
6hw5b00	04 Feb, 2019	3.60.20.10	Assigned
6hw5B00	04 Feb, 2019	3.60.20.10	Assigned
6hw5C00	04 Feb, 2019	3.60.20.10	Assigned
6hw5D00	04 Feb, 2019	3.60.20.10	Assigned
6hw5E00	04 Feb, 2019	3.60.20.10	Assigned
6hw5F00	04 Feb, 2019	3.60.20.10	Assigned
6hw5G00	04 Feb, 2019	3.60.20.10	Assigned
6hw5H00	04 Feb, 2019	3.60.20.10	Assigned
6hw5I00	04 Feb, 2019	3.60.20.10	Assigned
6hw5J00	04 Feb, 2019	3.60.20.10	Assigned
6hw5K00	04 Feb, 2019	3.60.20.10	Assigned
6hw5L00	04 Feb, 2019	3.60.20.10	Assigned
6hw5M00	04 Feb, 2019	3.60.20.10	Assigned
6hw5N00	04 Feb, 2019	3.60.20.10	Assigned
6hw5O00	04 Feb, 2019	3.60.20.10	Assigned
6hw5P00	04 Feb, 2019	3.60.20.10	Assigned
6hw5Q00	04 Feb, 2019	3.60.20.10	Assigned
6hw5R00	04 Feb, 2019	3.60.20.10	Assigned
6hw5S00	04 Feb, 2019	3.60.20.10	Assigned
6hw5T00	04 Feb, 2019	3.60.20.10	Assigned
6hw5U00	04 Feb, 2019	3.60.20.10	Assigned
6hw5V00	04 Feb, 2019	3.60.20.10	Assigned
6hw5W00	04 Feb, 2019	3.60.20.10	Assigned
6hw5X00	04 Feb, 2019	3.60.20.10	Assigned
6hw5Y00	04 Feb, 2019	3.60.20.10	Assigned
6hw5Z00	04 Feb, 2019	3.60.20.10	Assigned

UniProtKB Entries (28)

Accession	Gene ID	Taxon	Description
P40302	PSA6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-6
P21242	PSA7_YEAST	Saccharomyces cerevisiae S288C	Probable proteasome subunit alpha type-7
P32379	PSA5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-5
P40303	PSA4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-4
P25451	PSB3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-3
P25043	PSB2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-2
P22141	PSB4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-4
P23639	PSA2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-2
P25043	PSB2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-2
P23638	PSA3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-3
P23638	PSA3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-3
P25451	PSB3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-3
P40302	PSA6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-6
P30657	PSB7_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-7
P22141	PSB4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-4
P23724	PSB6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-6
P21243	PSA1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-1
P30657	PSB7_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-7
P21242	PSA7_YEAST	Saccharomyces cerevisiae S288C	Probable proteasome subunit alpha type-7
P30656	PSB5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-5
P23639	PSA2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-2
P23724	PSB6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-6
P30656	PSB5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-5
P32379	PSA5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-5
P40303	PSA4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-4
P21243	PSA1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-1
P38624	PSB1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-1
P38624	PSB1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-1