PDB 6hw3

PDB Links
Overview

PDB Information

PDB	6HW3
Method	X-RAY DIFFRACTION
Host Organism
Gene Source
Primary Citation	Structure-Based Design of Inhibitors Selective for Human Proteasome beta 2c or beta 2i Subunits. Xin, B.T., Huber, E.M., de Bruin, G., Heinemeyer, W., Maurits, E., Espinal, C., Du, Y., Janssens, M., Weyburne, E.S., Kisselev, A.F., Florea, B.I., Driessen, C., van der Marel, G.A., Groll, M., Overkleeft, H.S. J.Med.Chem.
Header	Hydrolase
Released	2018-10-11
Resolution	2.600
CATH Insert Date	03 Feb, 2019

PDB Images (57)

6hw3

PDB 6hw3

6hw3a

PDB Chain 6hw3a

6hw3A

PDB Chain 6hw3A

6hw3b

PDB Chain 6hw3b

6hw3B

PDB Chain 6hw3B

6hw3C

PDB Chain 6hw3C

6hw3D

PDB Chain 6hw3D

6hw3E

PDB Chain 6hw3E

6hw3F

PDB Chain 6hw3F

6hw3G

PDB Chain 6hw3G

6hw3H

PDB Chain 6hw3H

6hw3I

PDB Chain 6hw3I

6hw3J

PDB Chain 6hw3J

6hw3K

PDB Chain 6hw3K

6hw3L

PDB Chain 6hw3L

6hw3M

PDB Chain 6hw3M

6hw3N

PDB Chain 6hw3N

6hw3O

PDB Chain 6hw3O

6hw3P

PDB Chain 6hw3P

6hw3Q

PDB Chain 6hw3Q

6hw3R

PDB Chain 6hw3R

6hw3S

PDB Chain 6hw3S

6hw3T

PDB Chain 6hw3T

6hw3U

PDB Chain 6hw3U

6hw3V

PDB Chain 6hw3V

6hw3W

PDB Chain 6hw3W

6hw3X

PDB Chain 6hw3X

6hw3Y

PDB Chain 6hw3Y

6hw3Z

PDB Chain 6hw3Z

6hw3a00

CATH Domain 6hw3a00

6hw3A00

CATH Domain 6hw3A00

6hw3b00

CATH Domain 6hw3b00

6hw3B00

CATH Domain 6hw3B00

6hw3C00

CATH Domain 6hw3C00

6hw3D00

CATH Domain 6hw3D00

6hw3E00

CATH Domain 6hw3E00

6hw3F00

CATH Domain 6hw3F00

6hw3G00

CATH Domain 6hw3G00

6hw3H00

CATH Domain 6hw3H00

6hw3I00

CATH Domain 6hw3I00

6hw3J00

CATH Domain 6hw3J00

6hw3K00

CATH Domain 6hw3K00

6hw3L00

CATH Domain 6hw3L00

6hw3M00

CATH Domain 6hw3M00

6hw3N00

CATH Domain 6hw3N00

6hw3O00

CATH Domain 6hw3O00

6hw3P00

CATH Domain 6hw3P00

6hw3Q00

CATH Domain 6hw3Q00

6hw3R00

CATH Domain 6hw3R00

6hw3S00

CATH Domain 6hw3S00

6hw3T00

CATH Domain 6hw3T00

6hw3U00

CATH Domain 6hw3U00

6hw3V00

CATH Domain 6hw3V00

6hw3W00

CATH Domain 6hw3W00

6hw3X00

CATH Domain 6hw3X00

6hw3Y00

CATH Domain 6hw3Y00

6hw3Z00

CATH Domain 6hw3Z00

PDB Prints

PDB Chains (28)

Chain ID	Date inserted into CATH	CATH Status
a	03 Feb, 2019	Chopped
A	03 Feb, 2019	Chopped
b	03 Feb, 2019	Chopped
B	03 Feb, 2019	Chopped
C	03 Feb, 2019	Chopped
D	03 Feb, 2019	Chopped
E	03 Feb, 2019	Chopped
F	03 Feb, 2019	Chopped
G	03 Feb, 2019	Chopped
H	03 Feb, 2019	Chopped
I	03 Feb, 2019	Chopped
J	03 Feb, 2019	Chopped
K	03 Feb, 2019	Chopped
L	03 Feb, 2019	Chopped
M	03 Feb, 2019	Chopped
N	03 Feb, 2019	Chopped
O	03 Feb, 2019	Chopped
P	03 Feb, 2019	Chopped
Q	03 Feb, 2019	Chopped
R	03 Feb, 2019	Chopped
S	03 Feb, 2019	Chopped
T	03 Feb, 2019	Chopped
U	03 Feb, 2019	Chopped
V	03 Feb, 2019	Chopped
W	03 Feb, 2019	Chopped
X	03 Feb, 2019	Chopped
Y	03 Feb, 2019	Chopped
Z	03 Feb, 2019	Chopped

CATH Domains (28)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
6hw3a00	04 Feb, 2019	3.60.20.10	Assigned
6hw3A00	04 Feb, 2019	3.60.20.10	Assigned
6hw3b00	04 Feb, 2019	3.60.20.10	Assigned
6hw3B00	04 Feb, 2019	3.60.20.10	Assigned
6hw3C00	04 Feb, 2019	3.60.20.10	Assigned
6hw3D00	04 Feb, 2019	3.60.20.10	Assigned
6hw3E00	04 Feb, 2019	3.60.20.10	Assigned
6hw3F00	04 Feb, 2019	3.60.20.10	Assigned
6hw3G00	04 Feb, 2019	3.60.20.10	Assigned
6hw3H00	04 Feb, 2019	3.60.20.10	Assigned
6hw3I00	04 Feb, 2019	3.60.20.10	Assigned
6hw3J00	04 Feb, 2019	3.60.20.10	Assigned
6hw3K00	04 Feb, 2019	3.60.20.10	Assigned
6hw3L00	04 Feb, 2019	3.60.20.10	Assigned
6hw3M00	04 Feb, 2019	3.60.20.10	Assigned
6hw3N00	04 Feb, 2019	3.60.20.10	Assigned
6hw3O00	04 Feb, 2019	3.60.20.10	Assigned
6hw3P00	04 Feb, 2019	3.60.20.10	Assigned
6hw3Q00	04 Feb, 2019	3.60.20.10	Assigned
6hw3R00	04 Feb, 2019	3.60.20.10	Assigned
6hw3S00	04 Feb, 2019	3.60.20.10	Assigned
6hw3T00	04 Feb, 2019	3.60.20.10	Assigned
6hw3U00	04 Feb, 2019	3.60.20.10	Assigned
6hw3V00	04 Feb, 2019	3.60.20.10	Assigned
6hw3W00	04 Feb, 2019	3.60.20.10	Assigned
6hw3X00	04 Feb, 2019	3.60.20.10	Assigned
6hw3Y00	04 Feb, 2019	3.60.20.10	Assigned
6hw3Z00	04 Feb, 2019	3.60.20.10	Assigned

UniProtKB Entries (28)

Accession	Gene ID	Taxon	Description
P25451	PSB3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-3
P23724	PSB6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-6
P32379	PSA5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-5
P23639	PSA2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-2
P38624	PSB1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-1
P40303	PSA4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-4
P25451	PSB3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-3
P30657	PSB7_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-7
P21242	PSA7_YEAST	Saccharomyces cerevisiae S288C	Probable proteasome subunit alpha type-7
P25043	PSB2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-2
P21243	PSA1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-1
P30657	PSB7_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-7
P21242	PSA7_YEAST	Saccharomyces cerevisiae S288C	Probable proteasome subunit alpha type-7
P23638	PSA3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-3
P23724	PSB6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-6
P32379	PSA5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-5
P23639	PSA2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-2
P40303	PSA4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-4
P23638	PSA3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-3
P30656	PSB5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-5
P38624	PSB1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-1
P40302	PSA6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-6
P22141	PSB4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-4
P25043	PSB2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-2
P40302	PSA6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-6
P21243	PSA1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-1
P22141	PSB4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-4
P30656	PSB5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-5