PDB 6hvy

PDB Links
Overview

PDB Information

PDB	6HVY
Method	X-RAY DIFFRACTION
Host Organism
Gene Source
Primary Citation	Structure-Based Design of Inhibitors Selective for Human Proteasome beta 2c or beta 2i Subunits. Xin, B.T., Huber, E.M., de Bruin, G., Heinemeyer, W., Maurits, E., Espinal, C., Du, Y., Janssens, M., Weyburne, E.S., Kisselev, A.F., Florea, B.I., Driessen, C., van der Marel, G.A., Groll, M., Overkleeft, H.S. J.Med.Chem.
Header	Hydrolase
Released	2018-10-11
Resolution	2.700
CATH Insert Date	03 Feb, 2019

PDB Images (57)

6hvy

PDB 6hvy

6hvya

PDB Chain 6hvya

6hvyA

PDB Chain 6hvyA

6hvyb

PDB Chain 6hvyb

6hvyB

PDB Chain 6hvyB

6hvyC

PDB Chain 6hvyC

6hvyD

PDB Chain 6hvyD

6hvyE

PDB Chain 6hvyE

6hvyF

PDB Chain 6hvyF

6hvyG

PDB Chain 6hvyG

6hvyH

PDB Chain 6hvyH

6hvyI

PDB Chain 6hvyI

6hvyJ

PDB Chain 6hvyJ

6hvyK

PDB Chain 6hvyK

6hvyL

PDB Chain 6hvyL

6hvyM

PDB Chain 6hvyM

6hvyN

PDB Chain 6hvyN

6hvyO

PDB Chain 6hvyO

6hvyP

PDB Chain 6hvyP

6hvyQ

PDB Chain 6hvyQ

6hvyR

PDB Chain 6hvyR

6hvyS

PDB Chain 6hvyS

6hvyT

PDB Chain 6hvyT

6hvyU

PDB Chain 6hvyU

6hvyV

PDB Chain 6hvyV

6hvyW

PDB Chain 6hvyW

6hvyX

PDB Chain 6hvyX

6hvyY

PDB Chain 6hvyY

6hvyZ

PDB Chain 6hvyZ

6hvya00

CATH Domain 6hvya00

6hvyA00

CATH Domain 6hvyA00

6hvyb00

CATH Domain 6hvyb00

6hvyB00

CATH Domain 6hvyB00

6hvyC00

CATH Domain 6hvyC00

6hvyD00

CATH Domain 6hvyD00

6hvyE00

CATH Domain 6hvyE00

6hvyF00

CATH Domain 6hvyF00

6hvyG00

CATH Domain 6hvyG00

6hvyH00

CATH Domain 6hvyH00

6hvyI00

CATH Domain 6hvyI00

6hvyJ00

CATH Domain 6hvyJ00

6hvyK00

CATH Domain 6hvyK00

6hvyL00

CATH Domain 6hvyL00

6hvyM00

CATH Domain 6hvyM00

6hvyN00

CATH Domain 6hvyN00

6hvyO00

CATH Domain 6hvyO00

6hvyP00

CATH Domain 6hvyP00

6hvyQ00

CATH Domain 6hvyQ00

6hvyR00

CATH Domain 6hvyR00

6hvyS00

CATH Domain 6hvyS00

6hvyT00

CATH Domain 6hvyT00

6hvyU00

CATH Domain 6hvyU00

6hvyV00

CATH Domain 6hvyV00

6hvyW00

CATH Domain 6hvyW00

6hvyX00

CATH Domain 6hvyX00

6hvyY00

CATH Domain 6hvyY00

6hvyZ00

CATH Domain 6hvyZ00

PDB Prints

PDB Chains (28)

Chain ID	Date inserted into CATH	CATH Status
a	03 Feb, 2019	Chopped
A	03 Feb, 2019	Chopped
b	03 Feb, 2019	Chopped
B	03 Feb, 2019	Chopped
C	03 Feb, 2019	Chopped
D	03 Feb, 2019	Chopped
E	03 Feb, 2019	Chopped
F	03 Feb, 2019	Chopped
G	03 Feb, 2019	Chopped
H	03 Feb, 2019	Chopped
I	03 Feb, 2019	Chopped
J	03 Feb, 2019	Chopped
K	03 Feb, 2019	Chopped
L	03 Feb, 2019	Chopped
M	03 Feb, 2019	Chopped
N	03 Feb, 2019	Chopped
O	03 Feb, 2019	Chopped
P	03 Feb, 2019	Chopped
Q	03 Feb, 2019	Chopped
R	03 Feb, 2019	Chopped
S	03 Feb, 2019	Chopped
T	03 Feb, 2019	Chopped
U	03 Feb, 2019	Chopped
V	03 Feb, 2019	Chopped
W	03 Feb, 2019	Chopped
X	03 Feb, 2019	Chopped
Y	03 Feb, 2019	Chopped
Z	03 Feb, 2019	Chopped

CATH Domains (28)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
6hvya00	04 Feb, 2019	3.60.20.10	Assigned
6hvyA00	04 Feb, 2019	3.60.20.10	Assigned
6hvyb00	04 Feb, 2019	3.60.20.10	Assigned
6hvyB00	04 Feb, 2019	3.60.20.10	Assigned
6hvyC00	04 Feb, 2019	3.60.20.10	Assigned
6hvyD00	04 Feb, 2019	3.60.20.10	Assigned
6hvyE00	04 Feb, 2019	3.60.20.10	Assigned
6hvyF00	04 Feb, 2019	3.60.20.10	Assigned
6hvyG00	04 Feb, 2019	3.60.20.10	Assigned
6hvyH00	04 Feb, 2019	3.60.20.10	Assigned
6hvyI00	04 Feb, 2019	3.60.20.10	Assigned
6hvyJ00	04 Feb, 2019	3.60.20.10	Assigned
6hvyK00	04 Feb, 2019	3.60.20.10	Assigned
6hvyL00	04 Feb, 2019	3.60.20.10	Assigned
6hvyM00	04 Feb, 2019	3.60.20.10	Assigned
6hvyN00	04 Feb, 2019	3.60.20.10	Assigned
6hvyO00	04 Feb, 2019	3.60.20.10	Assigned
6hvyP00	04 Feb, 2019	3.60.20.10	Assigned
6hvyQ00	04 Feb, 2019	3.60.20.10	Assigned
6hvyR00	04 Feb, 2019	3.60.20.10	Assigned
6hvyS00	04 Feb, 2019	3.60.20.10	Assigned
6hvyT00	04 Feb, 2019	3.60.20.10	Assigned
6hvyU00	04 Feb, 2019	3.60.20.10	Assigned
6hvyV00	04 Feb, 2019	3.60.20.10	Assigned
6hvyW00	04 Feb, 2019	3.60.20.10	Assigned
6hvyX00	04 Feb, 2019	3.60.20.10	Assigned
6hvyY00	04 Feb, 2019	3.60.20.10	Assigned
6hvyZ00	04 Feb, 2019	3.60.20.10	Assigned

UniProtKB Entries (28)

Accession	Gene ID	Taxon	Description
P25043	PSB2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-2
P23638	PSA3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-3
P23639	PSA2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-2
P25451	PSB3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-3
P22141	PSB4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-4
P38624	PSB1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-1
P30656	PSB5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-5
P23639	PSA2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-2
P40302	PSA6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-6
P21243	PSA1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-1
P22141	PSB4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-4
P40303	PSA4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-4
P23724	PSB6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-6
P23724	PSB6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-6
P25043	PSB2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-2
P25451	PSB3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-3
P40302	PSA6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-6
P32379	PSA5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-5
P23638	PSA3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-3
P21243	PSA1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-1
P21242	PSA7_YEAST	Saccharomyces cerevisiae S288C	Probable proteasome subunit alpha type-7
P21242	PSA7_YEAST	Saccharomyces cerevisiae S288C	Probable proteasome subunit alpha type-7
P30656	PSB5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-5
P40303	PSA4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-4
P30657	PSB7_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-7
P30657	PSB7_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-7
P38624	PSB1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-1
P32379	PSA5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-5