PDB 6hvw

PDB Links
Overview

PDB Information

PDB	6HVW
Method	X-RAY DIFFRACTION
Host Organism	Saccharomyces cerevisiae S288c
Gene Source	Homo sapiens
Primary Citation	Structure-Based Design of Inhibitors Selective for Human Proteasome beta 2c or beta 2i Subunits. Xin, B.T., Huber, E.M., de Bruin, G., Heinemeyer, W., Maurits, E., Espinal, C., Du, Y., Janssens, M., Weyburne, E.S., Kisselev, A.F., Florea, B.I., Driessen, C., van der Marel, G.A., Groll, M., Overkleeft, H.S. J.Med.Chem.
Header	Hydrolase
Released	2018-10-11
Resolution	3.000
CATH Insert Date	03 Feb, 2019

PDB Images (57)

6hvw

PDB 6hvw

6hvwa

PDB Chain 6hvwa

6hvwA

PDB Chain 6hvwA

6hvwb

PDB Chain 6hvwb

6hvwB

PDB Chain 6hvwB

6hvwC

PDB Chain 6hvwC

6hvwD

PDB Chain 6hvwD

6hvwE

PDB Chain 6hvwE

6hvwF

PDB Chain 6hvwF

6hvwG

PDB Chain 6hvwG

6hvwH

PDB Chain 6hvwH

6hvwI

PDB Chain 6hvwI

6hvwJ

PDB Chain 6hvwJ

6hvwK

PDB Chain 6hvwK

6hvwL

PDB Chain 6hvwL

6hvwM

PDB Chain 6hvwM

6hvwN

PDB Chain 6hvwN

6hvwO

PDB Chain 6hvwO

6hvwP

PDB Chain 6hvwP

6hvwQ

PDB Chain 6hvwQ

6hvwR

PDB Chain 6hvwR

6hvwS

PDB Chain 6hvwS

6hvwT

PDB Chain 6hvwT

6hvwU

PDB Chain 6hvwU

6hvwV

PDB Chain 6hvwV

6hvwW

PDB Chain 6hvwW

6hvwX

PDB Chain 6hvwX

6hvwY

PDB Chain 6hvwY

6hvwZ

PDB Chain 6hvwZ

6hvwa00

CATH Domain 6hvwa00

6hvwA00

CATH Domain 6hvwA00

6hvwb00

CATH Domain 6hvwb00

6hvwB00

CATH Domain 6hvwB00

6hvwC00

CATH Domain 6hvwC00

6hvwD00

CATH Domain 6hvwD00

6hvwE00

CATH Domain 6hvwE00

6hvwF00

CATH Domain 6hvwF00

6hvwG00

CATH Domain 6hvwG00

6hvwH00

CATH Domain 6hvwH00

6hvwI00

CATH Domain 6hvwI00

6hvwJ00

CATH Domain 6hvwJ00

6hvwK00

CATH Domain 6hvwK00

6hvwL00

CATH Domain 6hvwL00

6hvwM00

CATH Domain 6hvwM00

6hvwN00

CATH Domain 6hvwN00

6hvwO00

CATH Domain 6hvwO00

6hvwP00

CATH Domain 6hvwP00

6hvwQ00

CATH Domain 6hvwQ00

6hvwR00

CATH Domain 6hvwR00

6hvwS00

CATH Domain 6hvwS00

6hvwT00

CATH Domain 6hvwT00

6hvwU00

CATH Domain 6hvwU00

6hvwV00

CATH Domain 6hvwV00

6hvwW00

CATH Domain 6hvwW00

6hvwX00

CATH Domain 6hvwX00

6hvwY00

CATH Domain 6hvwY00

6hvwZ00

CATH Domain 6hvwZ00

PDB Prints

PDB Chains (28)

Chain ID	Date inserted into CATH	CATH Status
a	03 Feb, 2019	Chopped
A	03 Feb, 2019	Chopped
b	03 Feb, 2019	Chopped
B	03 Feb, 2019	Chopped
C	03 Feb, 2019	Chopped
D	03 Feb, 2019	Chopped
E	03 Feb, 2019	Chopped
F	03 Feb, 2019	Chopped
G	03 Feb, 2019	Chopped
H	03 Feb, 2019	Chopped
I	03 Feb, 2019	Chopped
J	03 Feb, 2019	Chopped
K	03 Feb, 2019	Chopped
L	03 Feb, 2019	Chopped
M	03 Feb, 2019	Chopped
N	03 Feb, 2019	Chopped
O	03 Feb, 2019	Chopped
P	03 Feb, 2019	Chopped
Q	03 Feb, 2019	Chopped
R	03 Feb, 2019	Chopped
S	03 Feb, 2019	Chopped
T	03 Feb, 2019	Chopped
U	03 Feb, 2019	Chopped
V	03 Feb, 2019	Chopped
W	03 Feb, 2019	Chopped
X	03 Feb, 2019	Chopped
Y	03 Feb, 2019	Chopped
Z	03 Feb, 2019	Chopped

CATH Domains (28)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
6hvwa00	04 Feb, 2019	3.60.20.10	Assigned
6hvwA00	04 Feb, 2019	3.60.20.10	Assigned
6hvwb00	04 Feb, 2019	3.60.20.10	Assigned
6hvwB00	04 Feb, 2019	3.60.20.10	Assigned
6hvwC00	04 Feb, 2019	3.60.20.10	Assigned
6hvwD00	04 Feb, 2019	3.60.20.10	Assigned
6hvwE00	04 Feb, 2019	3.60.20.10	Assigned
6hvwF00	04 Feb, 2019	3.60.20.10	Assigned
6hvwG00	04 Feb, 2019	3.60.20.10	Assigned
6hvwH00	04 Feb, 2019	3.60.20.10	Assigned
6hvwI00	04 Feb, 2019	3.60.20.10	Assigned
6hvwJ00	04 Feb, 2019	3.60.20.10	Assigned
6hvwK00	04 Feb, 2019	3.60.20.10	Assigned
6hvwL00	04 Feb, 2019	3.60.20.10	Assigned
6hvwM00	04 Feb, 2019	3.60.20.10	Assigned
6hvwN00	04 Feb, 2019	3.60.20.10	Assigned
6hvwO00	04 Feb, 2019	3.60.20.10	Assigned
6hvwP00	04 Feb, 2019	3.60.20.10	Assigned
6hvwQ00	04 Feb, 2019	3.60.20.10	Assigned
6hvwR00	04 Feb, 2019	3.60.20.10	Assigned
6hvwS00	04 Feb, 2019	3.60.20.10	Assigned
6hvwT00	04 Feb, 2019	3.60.20.10	Assigned
6hvwU00	04 Feb, 2019	3.60.20.10	Assigned
6hvwV00	04 Feb, 2019	3.60.20.10	Assigned
6hvwW00	04 Feb, 2019	3.60.20.10	Assigned
6hvwX00	04 Feb, 2019	3.60.20.10	Assigned
6hvwY00	04 Feb, 2019	3.60.20.10	Assigned
6hvwZ00	04 Feb, 2019	3.60.20.10	Assigned

UniProtKB Entries (30)

Accession	Gene ID	Taxon	Description
P23724	PSB6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-6
P23639	PSA2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-2
P25451	PSB3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-3
P25451	PSB3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-3
P21243	PSA1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-1
P30656	PSB5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-5
P40303	PSA4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-4
P25043	PSB2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-2
P23638	PSA3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-3
P30656	PSB5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-5
P38624	PSB1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-1
P23724	PSB6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-6
P40306	PSB10_HUMAN	Homo sapiens	Proteasome subunit beta type-10
P21243	PSA1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-1
P40303	PSA4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-4
P21242	PSA7_YEAST	Saccharomyces cerevisiae S288C	Probable proteasome subunit alpha type-7
P38624	PSB1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-1
P32379	PSA5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-5
P23639	PSA2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-2
P25043	PSB2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-2
P40302	PSA6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-6
P40302	PSA6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-6
P40306	PSB10_HUMAN	Homo sapiens	Proteasome subunit beta type-10
P30657	PSB7_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-7
P21242	PSA7_YEAST	Saccharomyces cerevisiae S288C	Probable proteasome subunit alpha type-7
P22141	PSB4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-4
P32379	PSA5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-5
P23638	PSA3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-3
P30657	PSB7_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-7
P22141	PSB4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-4