PDB 6hvv

PDB Links
Overview

PDB Information

PDB	6HVV
Method	X-RAY DIFFRACTION
Host Organism	Saccharomyces cerevisiae S288C
Gene Source	Homo sapiens
Primary Citation	Structure-Based Design of Inhibitors Selective for Human Proteasome beta 2c or beta 2i Subunits. Xin, B.T., Huber, E.M., de Bruin, G., Heinemeyer, W., Maurits, E., Espinal, C., Du, Y., Janssens, M., Weyburne, E.S., Kisselev, A.F., Florea, B.I., Driessen, C., van der Marel, G.A., Groll, M., Overkleeft, H.S. J.Med.Chem.
Header	Hydrolase
Released	2018-10-11
Resolution	2.700
CATH Insert Date	03 Feb, 2019

PDB Images (57)

6hvv

PDB 6hvv

6hvva

PDB Chain 6hvva

6hvvA

PDB Chain 6hvvA

6hvvb

PDB Chain 6hvvb

6hvvB

PDB Chain 6hvvB

6hvvC

PDB Chain 6hvvC

6hvvD

PDB Chain 6hvvD

6hvvE

PDB Chain 6hvvE

6hvvF

PDB Chain 6hvvF

6hvvG

PDB Chain 6hvvG

6hvvH

PDB Chain 6hvvH

6hvvI

PDB Chain 6hvvI

6hvvJ

PDB Chain 6hvvJ

6hvvK

PDB Chain 6hvvK

6hvvL

PDB Chain 6hvvL

6hvvM

PDB Chain 6hvvM

6hvvN

PDB Chain 6hvvN

6hvvO

PDB Chain 6hvvO

6hvvP

PDB Chain 6hvvP

6hvvQ

PDB Chain 6hvvQ

6hvvR

PDB Chain 6hvvR

6hvvS

PDB Chain 6hvvS

6hvvT

PDB Chain 6hvvT

6hvvU

PDB Chain 6hvvU

6hvvV

PDB Chain 6hvvV

6hvvW

PDB Chain 6hvvW

6hvvX

PDB Chain 6hvvX

6hvvY

PDB Chain 6hvvY

6hvvZ

PDB Chain 6hvvZ

6hvva00

CATH Domain 6hvva00

6hvvA00

CATH Domain 6hvvA00

6hvvb00

CATH Domain 6hvvb00

6hvvB00

CATH Domain 6hvvB00

6hvvC00

CATH Domain 6hvvC00

6hvvD00

CATH Domain 6hvvD00

6hvvE00

CATH Domain 6hvvE00

6hvvF00

CATH Domain 6hvvF00

6hvvG00

CATH Domain 6hvvG00

6hvvH00

CATH Domain 6hvvH00

6hvvI00

CATH Domain 6hvvI00

6hvvJ00

CATH Domain 6hvvJ00

6hvvK00

CATH Domain 6hvvK00

6hvvL00

CATH Domain 6hvvL00

6hvvM00

CATH Domain 6hvvM00

6hvvN00

CATH Domain 6hvvN00

6hvvO00

CATH Domain 6hvvO00

6hvvP00

CATH Domain 6hvvP00

6hvvQ00

CATH Domain 6hvvQ00

6hvvR00

CATH Domain 6hvvR00

6hvvS00

CATH Domain 6hvvS00

6hvvT00

CATH Domain 6hvvT00

6hvvU00

CATH Domain 6hvvU00

6hvvV00

CATH Domain 6hvvV00

6hvvW00

CATH Domain 6hvvW00

6hvvX00

CATH Domain 6hvvX00

6hvvY00

CATH Domain 6hvvY00

6hvvZ00

CATH Domain 6hvvZ00

PDB Prints

PDB Chains (28)

Chain ID	Date inserted into CATH	CATH Status
a	03 Feb, 2019	Chopped
A	03 Feb, 2019	Chopped
b	03 Feb, 2019	Chopped
B	03 Feb, 2019	Chopped
C	03 Feb, 2019	Chopped
D	03 Feb, 2019	Chopped
E	03 Feb, 2019	Chopped
F	03 Feb, 2019	Chopped
G	03 Feb, 2019	Chopped
H	03 Feb, 2019	Chopped
I	03 Feb, 2019	Chopped
J	03 Feb, 2019	Chopped
K	03 Feb, 2019	Chopped
L	03 Feb, 2019	Chopped
M	03 Feb, 2019	Chopped
N	03 Feb, 2019	Chopped
O	03 Feb, 2019	Chopped
P	03 Feb, 2019	Chopped
Q	03 Feb, 2019	Chopped
R	03 Feb, 2019	Chopped
S	03 Feb, 2019	Chopped
T	03 Feb, 2019	Chopped
U	03 Feb, 2019	Chopped
V	03 Feb, 2019	Chopped
W	03 Feb, 2019	Chopped
X	03 Feb, 2019	Chopped
Y	03 Feb, 2019	Chopped
Z	03 Feb, 2019	Chopped

CATH Domains (28)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
6hvva00	04 Feb, 2019	3.60.20.10	Assigned
6hvvA00	04 Feb, 2019	3.60.20.10	Assigned
6hvvb00	04 Feb, 2019	3.60.20.10	Assigned
6hvvB00	04 Feb, 2019	3.60.20.10	Assigned
6hvvC00	04 Feb, 2019	3.60.20.10	Assigned
6hvvD00	04 Feb, 2019	3.60.20.10	Assigned
6hvvE00	04 Feb, 2019	3.60.20.10	Assigned
6hvvF00	04 Feb, 2019	3.60.20.10	Assigned
6hvvG00	04 Feb, 2019	3.60.20.10	Assigned
6hvvH00	04 Feb, 2019	3.60.20.10	Assigned
6hvvI00	04 Feb, 2019	3.60.20.10	Assigned
6hvvJ00	04 Feb, 2019	3.60.20.10	Assigned
6hvvK00	04 Feb, 2019	3.60.20.10	Assigned
6hvvL00	04 Feb, 2019	3.60.20.10	Assigned
6hvvM00	04 Feb, 2019	3.60.20.10	Assigned
6hvvN00	04 Feb, 2019	3.60.20.10	Assigned
6hvvO00	04 Feb, 2019	3.60.20.10	Assigned
6hvvP00	04 Feb, 2019	3.60.20.10	Assigned
6hvvQ00	04 Feb, 2019	3.60.20.10	Assigned
6hvvR00	04 Feb, 2019	3.60.20.10	Assigned
6hvvS00	04 Feb, 2019	3.60.20.10	Assigned
6hvvT00	04 Feb, 2019	3.60.20.10	Assigned
6hvvU00	04 Feb, 2019	3.60.20.10	Assigned
6hvvV00	04 Feb, 2019	3.60.20.10	Assigned
6hvvW00	04 Feb, 2019	3.60.20.10	Assigned
6hvvX00	04 Feb, 2019	3.60.20.10	Assigned
6hvvY00	04 Feb, 2019	3.60.20.10	Assigned
6hvvZ00	04 Feb, 2019	3.60.20.10	Assigned

UniProtKB Entries (30)

Accession	Gene ID	Taxon	Description
P22141	PSB4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-4
P38624	PSB1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-1
P21243	PSA1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-1
P21242	PSA7_YEAST	Saccharomyces cerevisiae S288C	Probable proteasome subunit alpha type-7
P40302	PSA6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-6
P40306	PSB10_HUMAN	Homo sapiens	Proteasome subunit beta type-10
P40303	PSA4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-4
P40303	PSA4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-4
P25043	PSB2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-2
P40302	PSA6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-6
P30657	PSB7_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-7
P25043	PSB2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-2
P25451	PSB3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-3
P21242	PSA7_YEAST	Saccharomyces cerevisiae S288C	Probable proteasome subunit alpha type-7
P30656	PSB5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-5
P30656	PSB5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-5
P25451	PSB3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-3
P22141	PSB4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-4
P32379	PSA5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-5
P23724	PSB6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-6
P23639	PSA2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-2
P23638	PSA3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-3
P23639	PSA2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-2
P23638	PSA3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-3
P21243	PSA1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-1
P38624	PSB1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-1
P32379	PSA5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-5
P23724	PSB6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-6
P40306	PSB10_HUMAN	Homo sapiens	Proteasome subunit beta type-10
P30657	PSB7_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-7