PDB 6hvu

PDB Links
Overview

PDB Information

PDB	6HVU
Method	X-RAY DIFFRACTION
Host Organism	Saccharomyces cerevisiae S288C
Gene Source	Homo sapiens
Primary Citation	Structure-Based Design of Inhibitors Selective for Human Proteasome beta 2c or beta 2i Subunits. Xin, B.T., Huber, E.M., de Bruin, G., Heinemeyer, W., Maurits, E., Espinal, C., Du, Y., Janssens, M., Weyburne, E.S., Kisselev, A.F., Florea, B.I., Driessen, C., van der Marel, G.A., Groll, M., Overkleeft, H.S. J.Med.Chem.
Header	Hydrolase
Released	2018-10-11
Resolution	2.900
CATH Insert Date	03 Feb, 2019

PDB Images (57)

6hvu

PDB 6hvu

6hvua

PDB Chain 6hvua

6hvuA

PDB Chain 6hvuA

6hvub

PDB Chain 6hvub

6hvuB

PDB Chain 6hvuB

6hvuC

PDB Chain 6hvuC

6hvuD

PDB Chain 6hvuD

6hvuE

PDB Chain 6hvuE

6hvuF

PDB Chain 6hvuF

6hvuG

PDB Chain 6hvuG

6hvuH

PDB Chain 6hvuH

6hvuI

PDB Chain 6hvuI

6hvuJ

PDB Chain 6hvuJ

6hvuK

PDB Chain 6hvuK

6hvuL

PDB Chain 6hvuL

6hvuM

PDB Chain 6hvuM

6hvuN

PDB Chain 6hvuN

6hvuO

PDB Chain 6hvuO

6hvuP

PDB Chain 6hvuP

6hvuQ

PDB Chain 6hvuQ

6hvuR

PDB Chain 6hvuR

6hvuS

PDB Chain 6hvuS

6hvuT

PDB Chain 6hvuT

6hvuU

PDB Chain 6hvuU

6hvuV

PDB Chain 6hvuV

6hvuW

PDB Chain 6hvuW

6hvuX

PDB Chain 6hvuX

6hvuY

PDB Chain 6hvuY

6hvuZ

PDB Chain 6hvuZ

6hvua00

CATH Domain 6hvua00

6hvuA00

CATH Domain 6hvuA00

6hvub00

CATH Domain 6hvub00

6hvuB00

CATH Domain 6hvuB00

6hvuC00

CATH Domain 6hvuC00

6hvuD00

CATH Domain 6hvuD00

6hvuE00

CATH Domain 6hvuE00

6hvuF00

CATH Domain 6hvuF00

6hvuG00

CATH Domain 6hvuG00

6hvuH00

CATH Domain 6hvuH00

6hvuI00

CATH Domain 6hvuI00

6hvuJ00

CATH Domain 6hvuJ00

6hvuK00

CATH Domain 6hvuK00

6hvuL00

CATH Domain 6hvuL00

6hvuM00

CATH Domain 6hvuM00

6hvuN00

CATH Domain 6hvuN00

6hvuO00

CATH Domain 6hvuO00

6hvuP00

CATH Domain 6hvuP00

6hvuQ00

CATH Domain 6hvuQ00

6hvuR00

CATH Domain 6hvuR00

6hvuS00

CATH Domain 6hvuS00

6hvuT00

CATH Domain 6hvuT00

6hvuU00

CATH Domain 6hvuU00

6hvuV00

CATH Domain 6hvuV00

6hvuW00

CATH Domain 6hvuW00

6hvuX00

CATH Domain 6hvuX00

6hvuY00

CATH Domain 6hvuY00

6hvuZ00

CATH Domain 6hvuZ00

PDB Prints

PDB Chains (28)

Chain ID	Date inserted into CATH	CATH Status
a	03 Feb, 2019	Chopped
A	03 Feb, 2019	Chopped
b	03 Feb, 2019	Chopped
B	03 Feb, 2019	Chopped
C	03 Feb, 2019	Chopped
D	03 Feb, 2019	Chopped
E	03 Feb, 2019	Chopped
F	03 Feb, 2019	Chopped
G	03 Feb, 2019	Chopped
H	03 Feb, 2019	Chopped
I	03 Feb, 2019	Chopped
J	03 Feb, 2019	Chopped
K	03 Feb, 2019	Chopped
L	03 Feb, 2019	Chopped
M	03 Feb, 2019	Chopped
N	03 Feb, 2019	Chopped
O	03 Feb, 2019	Chopped
P	03 Feb, 2019	Chopped
Q	03 Feb, 2019	Chopped
R	03 Feb, 2019	Chopped
S	03 Feb, 2019	Chopped
T	03 Feb, 2019	Chopped
U	03 Feb, 2019	Chopped
V	03 Feb, 2019	Chopped
W	03 Feb, 2019	Chopped
X	03 Feb, 2019	Chopped
Y	03 Feb, 2019	Chopped
Z	03 Feb, 2019	Chopped

CATH Domains (28)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
6hvua00	04 Feb, 2019	3.60.20.10	Assigned
6hvuA00	04 Feb, 2019	3.60.20.10	Assigned
6hvub00	04 Feb, 2019	3.60.20.10	Assigned
6hvuB00	04 Feb, 2019	3.60.20.10	Assigned
6hvuC00	04 Feb, 2019	3.60.20.10	Assigned
6hvuD00	04 Feb, 2019	3.60.20.10	Assigned
6hvuE00	04 Feb, 2019	3.60.20.10	Assigned
6hvuF00	04 Feb, 2019	3.60.20.10	Assigned
6hvuG00	04 Feb, 2019	3.60.20.10	Assigned
6hvuH00	04 Feb, 2019	3.60.20.10	Assigned
6hvuI00	04 Feb, 2019	3.60.20.10	Assigned
6hvuJ00	04 Feb, 2019	3.60.20.10	Assigned
6hvuK00	04 Feb, 2019	3.60.20.10	Assigned
6hvuL00	04 Feb, 2019	3.60.20.10	Assigned
6hvuM00	04 Feb, 2019	3.60.20.10	Assigned
6hvuN00	04 Feb, 2019	3.60.20.10	Assigned
6hvuO00	04 Feb, 2019	3.60.20.10	Assigned
6hvuP00	04 Feb, 2019	3.60.20.10	Assigned
6hvuQ00	04 Feb, 2019	3.60.20.10	Assigned
6hvuR00	04 Feb, 2019	3.60.20.10	Assigned
6hvuS00	04 Feb, 2019	3.60.20.10	Assigned
6hvuT00	04 Feb, 2019	3.60.20.10	Assigned
6hvuU00	04 Feb, 2019	3.60.20.10	Assigned
6hvuV00	04 Feb, 2019	3.60.20.10	Assigned
6hvuW00	04 Feb, 2019	3.60.20.10	Assigned
6hvuX00	04 Feb, 2019	3.60.20.10	Assigned
6hvuY00	04 Feb, 2019	3.60.20.10	Assigned
6hvuZ00	04 Feb, 2019	3.60.20.10	Assigned

UniProtKB Entries (30)

Accession	Gene ID	Taxon	Description
P25043	PSB2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-2
P23724	PSB6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-6
P21243	PSA1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-1
P38624	PSB1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-1
P30656	PSB5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-5
P32379	PSA5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-5
P23639	PSA2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-2
P21243	PSA1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-1
P21242	PSA7_YEAST	Saccharomyces cerevisiae S288C	Probable proteasome subunit alpha type-7
P38624	PSB1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-1
P23639	PSA2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-2
P40303	PSA4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-4
P25451	PSB3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-3
P40302	PSA6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-6
P25451	PSB3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-3
P40302	PSA6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-6
P40306	PSB10_HUMAN	Homo sapiens	Proteasome subunit beta type-10
P30657	PSB7_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-7
P22141	PSB4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-4
P22141	PSB4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-4
P30656	PSB5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-5
P23638	PSA3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-3
P21242	PSA7_YEAST	Saccharomyces cerevisiae S288C	Probable proteasome subunit alpha type-7
P25043	PSB2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-2
P40306	PSB10_HUMAN	Homo sapiens	Proteasome subunit beta type-10
P30657	PSB7_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-7
P32379	PSA5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-5
P40303	PSA4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-4
P23638	PSA3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-3
P23724	PSB6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-6