PDB 6hvt

PDB Links
Overview

PDB Information

PDB	6HVT
Method	X-RAY DIFFRACTION
Host Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Gene Source	Homo sapiens
Primary Citation	Structure-Based Design of Inhibitors Selective for Human Proteasome beta 2c or beta 2i Subunits. Xin, B.T., Huber, E.M., de Bruin, G., Heinemeyer, W., Maurits, E., Espinal, C., Du, Y., Janssens, M., Weyburne, E.S., Kisselev, A.F., Florea, B.I., Driessen, C., van der Marel, G.A., Groll, M., Overkleeft, H.S. J.Med.Chem.
Header	Hydrolase
Released	2018-10-11
Resolution	2.900
CATH Insert Date	03 Feb, 2019

PDB Images (57)

6hvt

PDB 6hvt

6hvta

PDB Chain 6hvta

6hvtA

PDB Chain 6hvtA

6hvtb

PDB Chain 6hvtb

6hvtB

PDB Chain 6hvtB

6hvtC

PDB Chain 6hvtC

6hvtD

PDB Chain 6hvtD

6hvtE

PDB Chain 6hvtE

6hvtF

PDB Chain 6hvtF

6hvtG

PDB Chain 6hvtG

6hvtH

PDB Chain 6hvtH

6hvtI

PDB Chain 6hvtI

6hvtJ

PDB Chain 6hvtJ

6hvtK

PDB Chain 6hvtK

6hvtL

PDB Chain 6hvtL

6hvtM

PDB Chain 6hvtM

6hvtN

PDB Chain 6hvtN

6hvtO

PDB Chain 6hvtO

6hvtP

PDB Chain 6hvtP

6hvtQ

PDB Chain 6hvtQ

6hvtR

PDB Chain 6hvtR

6hvtS

PDB Chain 6hvtS

6hvtT

PDB Chain 6hvtT

6hvtU

PDB Chain 6hvtU

6hvtV

PDB Chain 6hvtV

6hvtW

PDB Chain 6hvtW

6hvtX

PDB Chain 6hvtX

6hvtY

PDB Chain 6hvtY

6hvtZ

PDB Chain 6hvtZ

6hvta00

CATH Domain 6hvta00

6hvtA00

CATH Domain 6hvtA00

6hvtb00

CATH Domain 6hvtb00

6hvtB00

CATH Domain 6hvtB00

6hvtC00

CATH Domain 6hvtC00

6hvtD00

CATH Domain 6hvtD00

6hvtE00

CATH Domain 6hvtE00

6hvtF00

CATH Domain 6hvtF00

6hvtG00

CATH Domain 6hvtG00

6hvtH00

CATH Domain 6hvtH00

6hvtI00

CATH Domain 6hvtI00

6hvtJ00

CATH Domain 6hvtJ00

6hvtK00

CATH Domain 6hvtK00

6hvtL00

CATH Domain 6hvtL00

6hvtM00

CATH Domain 6hvtM00

6hvtN00

CATH Domain 6hvtN00

6hvtO00

CATH Domain 6hvtO00

6hvtP00

CATH Domain 6hvtP00

6hvtQ00

CATH Domain 6hvtQ00

6hvtR00

CATH Domain 6hvtR00

6hvtS00

CATH Domain 6hvtS00

6hvtT00

CATH Domain 6hvtT00

6hvtU00

CATH Domain 6hvtU00

6hvtV00

CATH Domain 6hvtV00

6hvtW00

CATH Domain 6hvtW00

6hvtX00

CATH Domain 6hvtX00

6hvtY00

CATH Domain 6hvtY00

6hvtZ00

CATH Domain 6hvtZ00

PDB Prints

PDB Chains (28)

Chain ID	Date inserted into CATH	CATH Status
a	03 Feb, 2019	Chopped
A	03 Feb, 2019	Chopped
b	03 Feb, 2019	Chopped
B	03 Feb, 2019	Chopped
C	03 Feb, 2019	Chopped
D	03 Feb, 2019	Chopped
E	03 Feb, 2019	Chopped
F	03 Feb, 2019	Chopped
G	03 Feb, 2019	Chopped
H	03 Feb, 2019	Chopped
I	03 Feb, 2019	Chopped
J	03 Feb, 2019	Chopped
K	03 Feb, 2019	Chopped
L	03 Feb, 2019	Chopped
M	03 Feb, 2019	Chopped
N	03 Feb, 2019	Chopped
O	03 Feb, 2019	Chopped
P	03 Feb, 2019	Chopped
Q	03 Feb, 2019	Chopped
R	03 Feb, 2019	Chopped
S	03 Feb, 2019	Chopped
T	03 Feb, 2019	Chopped
U	03 Feb, 2019	Chopped
V	03 Feb, 2019	Chopped
W	03 Feb, 2019	Chopped
X	03 Feb, 2019	Chopped
Y	03 Feb, 2019	Chopped
Z	03 Feb, 2019	Chopped

CATH Domains (28)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
6hvta00	04 Feb, 2019	3.60.20.10	Assigned
6hvtA00	04 Feb, 2019	3.60.20.10	Assigned
6hvtb00	04 Feb, 2019	3.60.20.10	Assigned
6hvtB00	04 Feb, 2019	3.60.20.10	Assigned
6hvtC00	04 Feb, 2019	3.60.20.10	Assigned
6hvtD00	04 Feb, 2019	3.60.20.10	Assigned
6hvtE00	04 Feb, 2019	3.60.20.10	Assigned
6hvtF00	04 Feb, 2019	3.60.20.10	Assigned
6hvtG00	04 Feb, 2019	3.60.20.10	Assigned
6hvtH00	04 Feb, 2019	3.60.20.10	Assigned
6hvtI00	04 Feb, 2019	3.60.20.10	Assigned
6hvtJ00	04 Feb, 2019	3.60.20.10	Assigned
6hvtK00	04 Feb, 2019	3.60.20.10	Assigned
6hvtL00	04 Feb, 2019	3.60.20.10	Assigned
6hvtM00	04 Feb, 2019	3.60.20.10	Assigned
6hvtN00	04 Feb, 2019	3.60.20.10	Assigned
6hvtO00	04 Feb, 2019	3.60.20.10	Assigned
6hvtP00	04 Feb, 2019	3.60.20.10	Assigned
6hvtQ00	04 Feb, 2019	3.60.20.10	Assigned
6hvtR00	04 Feb, 2019	3.60.20.10	Assigned
6hvtS00	04 Feb, 2019	3.60.20.10	Assigned
6hvtT00	04 Feb, 2019	3.60.20.10	Assigned
6hvtU00	04 Feb, 2019	3.60.20.10	Assigned
6hvtV00	04 Feb, 2019	3.60.20.10	Assigned
6hvtW00	04 Feb, 2019	3.60.20.10	Assigned
6hvtX00	04 Feb, 2019	3.60.20.10	Assigned
6hvtY00	04 Feb, 2019	3.60.20.10	Assigned
6hvtZ00	04 Feb, 2019	3.60.20.10	Assigned

UniProtKB Entries (30)

Accession	Gene ID	Taxon	Description
P40303	PSA4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-4
P25043	PSB2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-2
P25451	PSB3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-3
P21242	PSA7_YEAST	Saccharomyces cerevisiae S288C	Probable proteasome subunit alpha type-7
P32379	PSA5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-5
P23639	PSA2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-2
P21243	PSA1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-1
P38624	PSB1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-1
P23639	PSA2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-2
P30657	PSB7_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-7
P30656	PSB5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-5
P32379	PSA5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-5
P25043	PSB2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-2
P23638	PSA3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-3
P40302	PSA6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-6
P40302	PSA6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-6
P40306	PSB10_HUMAN	Homo sapiens	Proteasome subunit beta type-10
P21243	PSA1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-1
P22141	PSB4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-4
P38624	PSB1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-1
P23724	PSB6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-6
P23724	PSB6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-6
P22141	PSB4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-4
P30656	PSB5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-5
P40303	PSA4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-4
P25451	PSB3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-3
P40306	PSB10_HUMAN	Homo sapiens	Proteasome subunit beta type-10
P30657	PSB7_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-7
P23638	PSA3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-3
P21242	PSA7_YEAST	Saccharomyces cerevisiae S288C	Probable proteasome subunit alpha type-7