PDB 6hvr

PDB Links
Overview

PDB Information

PDB	6HVR
Method	X-RAY DIFFRACTION
Host Organism	Saccharomyces cerevisiae S288C
Gene Source	Homo sapiens
Primary Citation	Structure-Based Design of Inhibitors Selective for Human Proteasome beta 2c or beta 2i Subunits. Xin, B.T., Huber, E.M., de Bruin, G., Heinemeyer, W., Maurits, E., Espinal, C., Du, Y., Janssens, M., Weyburne, E.S., Kisselev, A.F., Florea, B.I., Driessen, C., van der Marel, G.A., Groll, M., Overkleeft, H.S. J.Med.Chem.
Header	Hydrolase
Released	2018-10-11
Resolution	2.700
CATH Insert Date	03 Feb, 2019

PDB Images (57)

6hvr

PDB 6hvr

6hvra

PDB Chain 6hvra

6hvrA

PDB Chain 6hvrA

6hvrb

PDB Chain 6hvrb

6hvrB

PDB Chain 6hvrB

6hvrC

PDB Chain 6hvrC

6hvrD

PDB Chain 6hvrD

6hvrE

PDB Chain 6hvrE

6hvrF

PDB Chain 6hvrF

6hvrG

PDB Chain 6hvrG

6hvrH

PDB Chain 6hvrH

6hvrI

PDB Chain 6hvrI

6hvrJ

PDB Chain 6hvrJ

6hvrK

PDB Chain 6hvrK

6hvrL

PDB Chain 6hvrL

6hvrM

PDB Chain 6hvrM

6hvrN

PDB Chain 6hvrN

6hvrO

PDB Chain 6hvrO

6hvrP

PDB Chain 6hvrP

6hvrQ

PDB Chain 6hvrQ

6hvrR

PDB Chain 6hvrR

6hvrS

PDB Chain 6hvrS

6hvrT

PDB Chain 6hvrT

6hvrU

PDB Chain 6hvrU

6hvrV

PDB Chain 6hvrV

6hvrW

PDB Chain 6hvrW

6hvrX

PDB Chain 6hvrX

6hvrY

PDB Chain 6hvrY

6hvrZ

PDB Chain 6hvrZ

6hvra00

CATH Domain 6hvra00

6hvrA00

CATH Domain 6hvrA00

6hvrb00

CATH Domain 6hvrb00

6hvrB00

CATH Domain 6hvrB00

6hvrC00

CATH Domain 6hvrC00

6hvrD00

CATH Domain 6hvrD00

6hvrE00

CATH Domain 6hvrE00

6hvrF00

CATH Domain 6hvrF00

6hvrG00

CATH Domain 6hvrG00

6hvrH00

CATH Domain 6hvrH00

6hvrI00

CATH Domain 6hvrI00

6hvrJ00

CATH Domain 6hvrJ00

6hvrK00

CATH Domain 6hvrK00

6hvrL00

CATH Domain 6hvrL00

6hvrM00

CATH Domain 6hvrM00

6hvrN00

CATH Domain 6hvrN00

6hvrO00

CATH Domain 6hvrO00

6hvrP00

CATH Domain 6hvrP00

6hvrQ00

CATH Domain 6hvrQ00

6hvrR00

CATH Domain 6hvrR00

6hvrS00

CATH Domain 6hvrS00

6hvrT00

CATH Domain 6hvrT00

6hvrU00

CATH Domain 6hvrU00

6hvrV00

CATH Domain 6hvrV00

6hvrW00

CATH Domain 6hvrW00

6hvrX00

CATH Domain 6hvrX00

6hvrY00

CATH Domain 6hvrY00

6hvrZ00

CATH Domain 6hvrZ00

PDB Prints

PDB Chains (28)

Chain ID	Date inserted into CATH	CATH Status
a	03 Feb, 2019	Chopped
A	03 Feb, 2019	Chopped
b	03 Feb, 2019	Chopped
B	03 Feb, 2019	Chopped
C	03 Feb, 2019	Chopped
D	03 Feb, 2019	Chopped
E	03 Feb, 2019	Chopped
F	03 Feb, 2019	Chopped
G	03 Feb, 2019	Chopped
H	03 Feb, 2019	Chopped
I	03 Feb, 2019	Chopped
J	03 Feb, 2019	Chopped
K	03 Feb, 2019	Chopped
L	03 Feb, 2019	Chopped
M	03 Feb, 2019	Chopped
N	03 Feb, 2019	Chopped
O	03 Feb, 2019	Chopped
P	03 Feb, 2019	Chopped
Q	03 Feb, 2019	Chopped
R	03 Feb, 2019	Chopped
S	03 Feb, 2019	Chopped
T	03 Feb, 2019	Chopped
U	03 Feb, 2019	Chopped
V	03 Feb, 2019	Chopped
W	03 Feb, 2019	Chopped
X	03 Feb, 2019	Chopped
Y	03 Feb, 2019	Chopped
Z	03 Feb, 2019	Chopped

CATH Domains (28)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
6hvra00	04 Feb, 2019	3.60.20.10	Assigned
6hvrA00	04 Feb, 2019	3.60.20.10	Assigned
6hvrb00	04 Feb, 2019	3.60.20.10	Assigned
6hvrB00	04 Feb, 2019	3.60.20.10	Assigned
6hvrC00	04 Feb, 2019	3.60.20.10	Assigned
6hvrD00	04 Feb, 2019	3.60.20.10	Assigned
6hvrE00	04 Feb, 2019	3.60.20.10	Assigned
6hvrF00	04 Feb, 2019	3.60.20.10	Assigned
6hvrG00	04 Feb, 2019	3.60.20.10	Assigned
6hvrH00	04 Feb, 2019	3.60.20.10	Assigned
6hvrI00	04 Feb, 2019	3.60.20.10	Assigned
6hvrJ00	04 Feb, 2019	3.60.20.10	Assigned
6hvrK00	04 Feb, 2019	3.60.20.10	Assigned
6hvrL00	04 Feb, 2019	3.60.20.10	Assigned
6hvrM00	04 Feb, 2019	3.60.20.10	Assigned
6hvrN00	04 Feb, 2019	3.60.20.10	Assigned
6hvrO00	04 Feb, 2019	3.60.20.10	Assigned
6hvrP00	04 Feb, 2019	3.60.20.10	Assigned
6hvrQ00	04 Feb, 2019	3.60.20.10	Assigned
6hvrR00	04 Feb, 2019	3.60.20.10	Assigned
6hvrS00	04 Feb, 2019	3.60.20.10	Assigned
6hvrT00	04 Feb, 2019	3.60.20.10	Assigned
6hvrU00	04 Feb, 2019	3.60.20.10	Assigned
6hvrV00	04 Feb, 2019	3.60.20.10	Assigned
6hvrW00	04 Feb, 2019	3.60.20.10	Assigned
6hvrX00	04 Feb, 2019	3.60.20.10	Assigned
6hvrY00	04 Feb, 2019	3.60.20.10	Assigned
6hvrZ00	04 Feb, 2019	3.60.20.10	Assigned

UniProtKB Entries (30)

Accession	Gene ID	Taxon	Description
P22141	PSB4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-4
P23639	PSA2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-2
P25043	PSB2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-2
P40306	PSB10_HUMAN	Homo sapiens	Proteasome subunit beta type-10
P21242	PSA7_YEAST	Saccharomyces cerevisiae S288C	Probable proteasome subunit alpha type-7
P22141	PSB4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-4
P32379	PSA5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-5
P25043	PSB2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-2
P40306	PSB10_HUMAN	Homo sapiens	Proteasome subunit beta type-10
P21243	PSA1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-1
P23639	PSA2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-2
P40303	PSA4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-4
P40302	PSA6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-6
P21243	PSA1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-1
P30657	PSB7_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-7
P30656	PSB5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-5
P32379	PSA5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-5
P40302	PSA6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-6
P23724	PSB6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-6
P21242	PSA7_YEAST	Saccharomyces cerevisiae S288C	Probable proteasome subunit alpha type-7
P38624	PSB1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-1
P40303	PSA4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-4
P23638	PSA3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-3
P25451	PSB3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-3
P23724	PSB6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-6
P30656	PSB5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-5
P23638	PSA3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-3
P25451	PSB3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-3
P30657	PSB7_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-7
P38624	PSB1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-1