PDB 6hva

PDB Links
Overview

PDB Information

PDB	6HVA
Method	X-RAY DIFFRACTION
Host Organism	Saccharomyces cerevisiae S288C
Gene Source	Homo sapiens
Primary Citation	Structure-Based Design of Inhibitors Selective for Human Proteasome beta 2c or beta 2i Subunits. Xin, B.T., Huber, E.M., de Bruin, G., Heinemeyer, W., Maurits, E., Espinal, C., Du, Y., Janssens, M., Weyburne, E.S., Kisselev, A.F., Florea, B.I., Driessen, C., van der Marel, G.A., Groll, M., Overkleeft, H.S. J.Med.Chem.
Header	Hydrolase
Released	2018-10-10
Resolution	2.900
CATH Insert Date	03 Feb, 2019

PDB Images (57)

6hva

PDB 6hva

6hvaa

PDB Chain 6hvaa

6hvaA

PDB Chain 6hvaA

6hvab

PDB Chain 6hvab

6hvaB

PDB Chain 6hvaB

6hvaC

PDB Chain 6hvaC

6hvaD

PDB Chain 6hvaD

6hvaE

PDB Chain 6hvaE

6hvaF

PDB Chain 6hvaF

6hvaG

PDB Chain 6hvaG

6hvaH

PDB Chain 6hvaH

6hvaI

PDB Chain 6hvaI

6hvaJ

PDB Chain 6hvaJ

6hvaK

PDB Chain 6hvaK

6hvaL

PDB Chain 6hvaL

6hvaM

PDB Chain 6hvaM

6hvaN

PDB Chain 6hvaN

6hvaO

PDB Chain 6hvaO

6hvaP

PDB Chain 6hvaP

6hvaQ

PDB Chain 6hvaQ

6hvaR

PDB Chain 6hvaR

6hvaS

PDB Chain 6hvaS

6hvaT

PDB Chain 6hvaT

6hvaU

PDB Chain 6hvaU

6hvaV

PDB Chain 6hvaV

6hvaW

PDB Chain 6hvaW

6hvaX

PDB Chain 6hvaX

6hvaY

PDB Chain 6hvaY

6hvaZ

PDB Chain 6hvaZ

6hvaa00

CATH Domain 6hvaa00

6hvaA00

CATH Domain 6hvaA00

6hvab00

CATH Domain 6hvab00

6hvaB00

CATH Domain 6hvaB00

6hvaC00

CATH Domain 6hvaC00

6hvaD00

CATH Domain 6hvaD00

6hvaE00

CATH Domain 6hvaE00

6hvaF00

CATH Domain 6hvaF00

6hvaG00

CATH Domain 6hvaG00

6hvaH00

CATH Domain 6hvaH00

6hvaI00

CATH Domain 6hvaI00

6hvaJ00

CATH Domain 6hvaJ00

6hvaK00

CATH Domain 6hvaK00

6hvaL00

CATH Domain 6hvaL00

6hvaM00

CATH Domain 6hvaM00

6hvaN00

CATH Domain 6hvaN00

6hvaO00

CATH Domain 6hvaO00

6hvaP00

CATH Domain 6hvaP00

6hvaQ00

CATH Domain 6hvaQ00

6hvaR00

CATH Domain 6hvaR00

6hvaS00

CATH Domain 6hvaS00

6hvaT00

CATH Domain 6hvaT00

6hvaU00

CATH Domain 6hvaU00

6hvaV00

CATH Domain 6hvaV00

6hvaW00

CATH Domain 6hvaW00

6hvaX00

CATH Domain 6hvaX00

6hvaY00

CATH Domain 6hvaY00

6hvaZ00

CATH Domain 6hvaZ00

PDB Prints

PDB Chains (28)

Chain ID	Date inserted into CATH	CATH Status
a	03 Feb, 2019	Chopped
A	03 Feb, 2019	Chopped
b	03 Feb, 2019	Chopped
B	03 Feb, 2019	Chopped
C	03 Feb, 2019	Chopped
D	03 Feb, 2019	Chopped
E	03 Feb, 2019	Chopped
F	03 Feb, 2019	Chopped
G	03 Feb, 2019	Chopped
H	03 Feb, 2019	Chopped
I	03 Feb, 2019	Chopped
J	03 Feb, 2019	Chopped
K	03 Feb, 2019	Chopped
L	03 Feb, 2019	Chopped
M	03 Feb, 2019	Chopped
N	03 Feb, 2019	Chopped
O	03 Feb, 2019	Chopped
P	03 Feb, 2019	Chopped
Q	03 Feb, 2019	Chopped
R	03 Feb, 2019	Chopped
S	03 Feb, 2019	Chopped
T	03 Feb, 2019	Chopped
U	03 Feb, 2019	Chopped
V	03 Feb, 2019	Chopped
W	03 Feb, 2019	Chopped
X	03 Feb, 2019	Chopped
Y	03 Feb, 2019	Chopped
Z	03 Feb, 2019	Chopped

CATH Domains (28)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
6hvaa00	04 Feb, 2019	3.60.20.10	Assigned
6hvaA00	04 Feb, 2019	3.60.20.10	Assigned
6hvab00	04 Feb, 2019	3.60.20.10	Assigned
6hvaB00	04 Feb, 2019	3.60.20.10	Assigned
6hvaC00	04 Feb, 2019	3.60.20.10	Assigned
6hvaD00	04 Feb, 2019	3.60.20.10	Assigned
6hvaE00	04 Feb, 2019	3.60.20.10	Assigned
6hvaF00	04 Feb, 2019	3.60.20.10	Assigned
6hvaG00	04 Feb, 2019	3.60.20.10	Assigned
6hvaH00	04 Feb, 2019	3.60.20.10	Assigned
6hvaI00	04 Feb, 2019	3.60.20.10	Assigned
6hvaJ00	04 Feb, 2019	3.60.20.10	Assigned
6hvaK00	04 Feb, 2019	3.60.20.10	Assigned
6hvaL00	04 Feb, 2019	3.60.20.10	Assigned
6hvaM00	04 Feb, 2019	3.60.20.10	Assigned
6hvaN00	04 Feb, 2019	3.60.20.10	Assigned
6hvaO00	04 Feb, 2019	3.60.20.10	Assigned
6hvaP00	04 Feb, 2019	3.60.20.10	Assigned
6hvaQ00	04 Feb, 2019	3.60.20.10	Assigned
6hvaR00	04 Feb, 2019	3.60.20.10	Assigned
6hvaS00	04 Feb, 2019	3.60.20.10	Assigned
6hvaT00	04 Feb, 2019	3.60.20.10	Assigned
6hvaU00	04 Feb, 2019	3.60.20.10	Assigned
6hvaV00	04 Feb, 2019	3.60.20.10	Assigned
6hvaW00	04 Feb, 2019	3.60.20.10	Assigned
6hvaX00	04 Feb, 2019	3.60.20.10	Assigned
6hvaY00	04 Feb, 2019	3.60.20.10	Assigned
6hvaZ00	04 Feb, 2019	3.60.20.10	Assigned

UniProtKB Entries (30)

Accession	Gene ID	Taxon	Description
P23639	PSA2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-2
P40302	PSA6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-6
P32379	PSA5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-5
P23724	PSB6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-6
P30657	PSB7_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-7
P21242	PSA7_YEAST	Saccharomyces cerevisiae S288C	Probable proteasome subunit alpha type-7
P22141	PSB4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-4
P30656	PSB5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-5
P30656	PSB5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-5
P38624	PSB1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-1
P40303	PSA4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-4
P40306	PSB10_HUMAN	Homo sapiens	Proteasome subunit beta type-10
P21243	PSA1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-1
P30657	PSB7_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-7
P21242	PSA7_YEAST	Saccharomyces cerevisiae S288C	Probable proteasome subunit alpha type-7
P40302	PSA6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-6
P25043	PSB2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-2
P23638	PSA3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-3
P23638	PSA3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-3
P38624	PSB1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-1
P32379	PSA5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-5
P25043	PSB2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-2
P21243	PSA1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-1
P23639	PSA2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-2
P40303	PSA4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-4
P25451	PSB3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-3
P25451	PSB3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-3
P23724	PSB6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-6
P40306	PSB10_HUMAN	Homo sapiens	Proteasome subunit beta type-10
P22141	PSB4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-4