PDB 6hv4

PDB Links
Overview

PDB Information

PDB	6HV4
Method	X-RAY DIFFRACTION
Host Organism	Saccharomyces cerevisiae
Gene Source	Homo sapiens
Primary Citation	Structure-Based Design of Inhibitors Selective for Human Proteasome beta 2c or beta 2i Subunits. Xin, B.T., Huber, E.M., de Bruin, G., Heinemeyer, W., Maurits, E., Espinal, C., Du, Y., Janssens, M., Weyburne, E.S., Kisselev, A.F., Florea, B.I., Driessen, C., van der Marel, G.A., Groll, M., Overkleeft, H.S. J.Med.Chem.
Header	Hydrolase
Released	2018-10-10
Resolution	3.000
CATH Insert Date	03 Feb, 2019

PDB Images (57)

6hv4

PDB 6hv4

6hv4a

PDB Chain 6hv4a

6hv4A

PDB Chain 6hv4A

6hv4b

PDB Chain 6hv4b

6hv4B

PDB Chain 6hv4B

6hv4C

PDB Chain 6hv4C

6hv4D

PDB Chain 6hv4D

6hv4E

PDB Chain 6hv4E

6hv4F

PDB Chain 6hv4F

6hv4G

PDB Chain 6hv4G

6hv4H

PDB Chain 6hv4H

6hv4I

PDB Chain 6hv4I

6hv4J

PDB Chain 6hv4J

6hv4K

PDB Chain 6hv4K

6hv4L

PDB Chain 6hv4L

6hv4M

PDB Chain 6hv4M

6hv4N

PDB Chain 6hv4N

6hv4O

PDB Chain 6hv4O

6hv4P

PDB Chain 6hv4P

6hv4Q

PDB Chain 6hv4Q

6hv4R

PDB Chain 6hv4R

6hv4S

PDB Chain 6hv4S

6hv4T

PDB Chain 6hv4T

6hv4U

PDB Chain 6hv4U

6hv4V

PDB Chain 6hv4V

6hv4W

PDB Chain 6hv4W

6hv4X

PDB Chain 6hv4X

6hv4Y

PDB Chain 6hv4Y

6hv4Z

PDB Chain 6hv4Z

6hv4a00

CATH Domain 6hv4a00

6hv4A00

CATH Domain 6hv4A00

6hv4b00

CATH Domain 6hv4b00

6hv4B00

CATH Domain 6hv4B00

6hv4C00

CATH Domain 6hv4C00

6hv4D00

CATH Domain 6hv4D00

6hv4E00

CATH Domain 6hv4E00

6hv4F00

CATH Domain 6hv4F00

6hv4G00

CATH Domain 6hv4G00

6hv4H00

CATH Domain 6hv4H00

6hv4I00

CATH Domain 6hv4I00

6hv4J00

CATH Domain 6hv4J00

6hv4K00

CATH Domain 6hv4K00

6hv4L00

CATH Domain 6hv4L00

6hv4M00

CATH Domain 6hv4M00

6hv4N00

CATH Domain 6hv4N00

6hv4O00

CATH Domain 6hv4O00

6hv4P00

CATH Domain 6hv4P00

6hv4Q00

CATH Domain 6hv4Q00

6hv4R00

CATH Domain 6hv4R00

6hv4S00

CATH Domain 6hv4S00

6hv4T00

CATH Domain 6hv4T00

6hv4U00

CATH Domain 6hv4U00

6hv4V00

CATH Domain 6hv4V00

6hv4W00

CATH Domain 6hv4W00

6hv4X00

CATH Domain 6hv4X00

6hv4Y00

CATH Domain 6hv4Y00

6hv4Z00

CATH Domain 6hv4Z00

PDB Prints

PDB Chains (28)

Chain ID	Date inserted into CATH	CATH Status
a	03 Feb, 2019	Chopped
A	03 Feb, 2019	Chopped
b	03 Feb, 2019	Chopped
B	03 Feb, 2019	Chopped
C	03 Feb, 2019	Chopped
D	03 Feb, 2019	Chopped
E	03 Feb, 2019	Chopped
F	03 Feb, 2019	Chopped
G	03 Feb, 2019	Chopped
H	03 Feb, 2019	Chopped
I	03 Feb, 2019	Chopped
J	03 Feb, 2019	Chopped
K	03 Feb, 2019	Chopped
L	03 Feb, 2019	Chopped
M	03 Feb, 2019	Chopped
N	03 Feb, 2019	Chopped
O	03 Feb, 2019	Chopped
P	03 Feb, 2019	Chopped
Q	03 Feb, 2019	Chopped
R	03 Feb, 2019	Chopped
S	03 Feb, 2019	Chopped
T	03 Feb, 2019	Chopped
U	03 Feb, 2019	Chopped
V	03 Feb, 2019	Chopped
W	03 Feb, 2019	Chopped
X	03 Feb, 2019	Chopped
Y	03 Feb, 2019	Chopped
Z	03 Feb, 2019	Chopped

CATH Domains (28)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
6hv4a00	04 Feb, 2019	3.60.20.10	Assigned
6hv4A00	04 Feb, 2019	3.60.20.10	Assigned
6hv4b00	04 Feb, 2019	3.60.20.10	Assigned
6hv4B00	04 Feb, 2019	3.60.20.10	Assigned
6hv4C00	04 Feb, 2019	3.60.20.10	Assigned
6hv4D00	04 Feb, 2019	3.60.20.10	Assigned
6hv4E00	04 Feb, 2019	3.60.20.10	Assigned
6hv4F00	04 Feb, 2019	3.60.20.10	Assigned
6hv4G00	04 Feb, 2019	3.60.20.10	Assigned
6hv4H00	04 Feb, 2019	3.60.20.10	Assigned
6hv4I00	04 Feb, 2019	3.60.20.10	Assigned
6hv4J00	04 Feb, 2019	3.60.20.10	Assigned
6hv4K00	04 Feb, 2019	3.60.20.10	Assigned
6hv4L00	04 Feb, 2019	3.60.20.10	Assigned
6hv4M00	04 Feb, 2019	3.60.20.10	Assigned
6hv4N00	04 Feb, 2019	3.60.20.10	Assigned
6hv4O00	04 Feb, 2019	3.60.20.10	Assigned
6hv4P00	04 Feb, 2019	3.60.20.10	Assigned
6hv4Q00	04 Feb, 2019	3.60.20.10	Assigned
6hv4R00	04 Feb, 2019	3.60.20.10	Assigned
6hv4S00	04 Feb, 2019	3.60.20.10	Assigned
6hv4T00	04 Feb, 2019	3.60.20.10	Assigned
6hv4U00	04 Feb, 2019	3.60.20.10	Assigned
6hv4V00	04 Feb, 2019	3.60.20.10	Assigned
6hv4W00	04 Feb, 2019	3.60.20.10	Assigned
6hv4X00	04 Feb, 2019	3.60.20.10	Assigned
6hv4Y00	04 Feb, 2019	3.60.20.10	Assigned
6hv4Z00	04 Feb, 2019	3.60.20.10	Assigned

UniProtKB Entries (30)

Accession	Gene ID	Taxon	Description
P25043	PSB2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-2
P23639	PSA2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-2
P25451	PSB3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-3
P25451	PSB3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-3
P40302	PSA6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-6
P23724	PSB6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-6
P22141	PSB4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-4
P32379	PSA5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-5
P21242	PSA7_YEAST	Saccharomyces cerevisiae S288C	Probable proteasome subunit alpha type-7
P21242	PSA7_YEAST	Saccharomyces cerevisiae S288C	Probable proteasome subunit alpha type-7
P23639	PSA2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-2
P25043	PSB2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-2
P23638	PSA3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-3
P32379	PSA5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-5
P40303	PSA4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-4
P30657	PSB7_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-7
P30656	PSB5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-5
P21243	PSA1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-1
P21243	PSA1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-1
P38624	PSB1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-1
P40306	PSB10_HUMAN	Homo sapiens	Proteasome subunit beta type-10
P23724	PSB6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-6
P30657	PSB7_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-7
P40303	PSA4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-4
P40302	PSA6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-6
P40306	PSB10_HUMAN	Homo sapiens	Proteasome subunit beta type-10
P38624	PSB1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-1
P22141	PSB4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-4
P30656	PSB5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-5
P23638	PSA3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-3