PDB 6huv

PDB Links
Overview

PDB Information

PDB	6HUV
Method	X-RAY DIFFRACTION
Host Organism	Saccharomyces cerevisiae
Gene Source	Homo sapiens
Primary Citation	Structure-Based Design of Inhibitors Selective for Human Proteasome beta 2c or beta 2i Subunits. Xin, B.T., Huber, E.M., de Bruin, G., Heinemeyer, W., Maurits, E., Espinal, C., Du, Y., Janssens, M., Weyburne, E.S., Kisselev, A.F., Florea, B.I., Driessen, C., van der Marel, G.A., Groll, M., Overkleeft, H.S. J.Med.Chem.
Header	Hydrolase
Released	2018-10-09
Resolution	3.100
CATH Insert Date	03 Feb, 2019

PDB Images (57)

6huv

PDB 6huv

6huva

PDB Chain 6huva

6huvA

PDB Chain 6huvA

6huvb

PDB Chain 6huvb

6huvB

PDB Chain 6huvB

6huvC

PDB Chain 6huvC

6huvD

PDB Chain 6huvD

6huvE

PDB Chain 6huvE

6huvF

PDB Chain 6huvF

6huvG

PDB Chain 6huvG

6huvH

PDB Chain 6huvH

6huvI

PDB Chain 6huvI

6huvJ

PDB Chain 6huvJ

6huvK

PDB Chain 6huvK

6huvL

PDB Chain 6huvL

6huvM

PDB Chain 6huvM

6huvN

PDB Chain 6huvN

6huvO

PDB Chain 6huvO

6huvP

PDB Chain 6huvP

6huvQ

PDB Chain 6huvQ

6huvR

PDB Chain 6huvR

6huvS

PDB Chain 6huvS

6huvT

PDB Chain 6huvT

6huvU

PDB Chain 6huvU

6huvV

PDB Chain 6huvV

6huvW

PDB Chain 6huvW

6huvX

PDB Chain 6huvX

6huvY

PDB Chain 6huvY

6huvZ

PDB Chain 6huvZ

6huva00

CATH Domain 6huva00

6huvA00

CATH Domain 6huvA00

6huvb00

CATH Domain 6huvb00

6huvB00

CATH Domain 6huvB00

6huvC00

CATH Domain 6huvC00

6huvD00

CATH Domain 6huvD00

6huvE00

CATH Domain 6huvE00

6huvF00

CATH Domain 6huvF00

6huvG00

CATH Domain 6huvG00

6huvH00

CATH Domain 6huvH00

6huvI00

CATH Domain 6huvI00

6huvJ00

CATH Domain 6huvJ00

6huvK00

CATH Domain 6huvK00

6huvL00

CATH Domain 6huvL00

6huvM00

CATH Domain 6huvM00

6huvN00

CATH Domain 6huvN00

6huvO00

CATH Domain 6huvO00

6huvP00

CATH Domain 6huvP00

6huvQ00

CATH Domain 6huvQ00

6huvR00

CATH Domain 6huvR00

6huvS00

CATH Domain 6huvS00

6huvT00

CATH Domain 6huvT00

6huvU00

CATH Domain 6huvU00

6huvV00

CATH Domain 6huvV00

6huvW00

CATH Domain 6huvW00

6huvX00

CATH Domain 6huvX00

6huvY00

CATH Domain 6huvY00

6huvZ00

CATH Domain 6huvZ00

PDB Prints

PDB Chains (28)

Chain ID	Date inserted into CATH	CATH Status
a	03 Feb, 2019	Chopped
A	03 Feb, 2019	Chopped
b	03 Feb, 2019	Chopped
B	03 Feb, 2019	Chopped
C	03 Feb, 2019	Chopped
D	03 Feb, 2019	Chopped
E	03 Feb, 2019	Chopped
F	03 Feb, 2019	Chopped
G	03 Feb, 2019	Chopped
H	03 Feb, 2019	Chopped
I	03 Feb, 2019	Chopped
J	03 Feb, 2019	Chopped
K	03 Feb, 2019	Chopped
L	03 Feb, 2019	Chopped
M	03 Feb, 2019	Chopped
N	03 Feb, 2019	Chopped
O	03 Feb, 2019	Chopped
P	03 Feb, 2019	Chopped
Q	03 Feb, 2019	Chopped
R	03 Feb, 2019	Chopped
S	03 Feb, 2019	Chopped
T	03 Feb, 2019	Chopped
U	03 Feb, 2019	Chopped
V	03 Feb, 2019	Chopped
W	03 Feb, 2019	Chopped
X	03 Feb, 2019	Chopped
Y	03 Feb, 2019	Chopped
Z	03 Feb, 2019	Chopped

CATH Domains (28)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
6huva00	04 Feb, 2019	3.60.20.10	Assigned
6huvA00	04 Feb, 2019	3.60.20.10	Assigned
6huvb00	04 Feb, 2019	3.60.20.10	Assigned
6huvB00	04 Feb, 2019	3.60.20.10	Assigned
6huvC00	04 Feb, 2019	3.60.20.10	Assigned
6huvD00	04 Feb, 2019	3.60.20.10	Assigned
6huvE00	04 Feb, 2019	3.60.20.10	Assigned
6huvF00	04 Feb, 2019	3.60.20.10	Assigned
6huvG00	04 Feb, 2019	3.60.20.10	Assigned
6huvH00	04 Feb, 2019	3.60.20.10	Assigned
6huvI00	04 Feb, 2019	3.60.20.10	Assigned
6huvJ00	04 Feb, 2019	3.60.20.10	Assigned
6huvK00	04 Feb, 2019	3.60.20.10	Assigned
6huvL00	04 Feb, 2019	3.60.20.10	Assigned
6huvM00	04 Feb, 2019	3.60.20.10	Assigned
6huvN00	04 Feb, 2019	3.60.20.10	Assigned
6huvO00	04 Feb, 2019	3.60.20.10	Assigned
6huvP00	04 Feb, 2019	3.60.20.10	Assigned
6huvQ00	04 Feb, 2019	3.60.20.10	Assigned
6huvR00	04 Feb, 2019	3.60.20.10	Assigned
6huvS00	04 Feb, 2019	3.60.20.10	Assigned
6huvT00	04 Feb, 2019	3.60.20.10	Assigned
6huvU00	04 Feb, 2019	3.60.20.10	Assigned
6huvV00	04 Feb, 2019	3.60.20.10	Assigned
6huvW00	04 Feb, 2019	3.60.20.10	Assigned
6huvX00	04 Feb, 2019	3.60.20.10	Assigned
6huvY00	04 Feb, 2019	3.60.20.10	Assigned
6huvZ00	04 Feb, 2019	3.60.20.10	Assigned

UniProtKB Entries (28)

Accession	Gene ID	Taxon	Description
P23639	PSA2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-2
Q99436	PSB7_HUMAN	Homo sapiens	Proteasome subunit beta type-7
P40302	PSA6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-6
P23638	PSA3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-3
P25451	PSB3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-3
P21242	PSA7_YEAST	Saccharomyces cerevisiae S288C	Probable proteasome subunit alpha type-7
P22141	PSB4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-4
P21243	PSA1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-1
P23638	PSA3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-3
P25451	PSB3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-3
P30657	PSB7_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-7
P40303	PSA4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-4
P22141	PSB4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-4
P21242	PSA7_YEAST	Saccharomyces cerevisiae S288C	Probable proteasome subunit alpha type-7
P38624	PSB1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-1
P40303	PSA4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-4
P23724	PSB6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-6
P23724	PSB6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-6
P30656	PSB5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-5
P32379	PSA5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-5
P32379	PSA5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-5
Q99436	PSB7_HUMAN	Homo sapiens	Proteasome subunit beta type-7
P38624	PSB1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-1
P30656	PSB5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-5
P23639	PSA2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-2
P40302	PSA6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-6
P21243	PSA1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-1
P30657	PSB7_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-7