PDB 6huq

PDB Links
Overview

PDB Information

PDB	6HUQ
Method	X-RAY DIFFRACTION
Host Organism	Saccharomyces cerevisiae
Gene Source	Homo sapiens
Primary Citation	Structure-Based Design of Inhibitors Selective for Human Proteasome beta 2c or beta 2i Subunits. Xin, B.T., Huber, E.M., de Bruin, G., Heinemeyer, W., Maurits, E., Espinal, C., Du, Y., Janssens, M., Weyburne, E.S., Kisselev, A.F., Florea, B.I., Driessen, C., van der Marel, G.A., Groll, M., Overkleeft, H.S. J.Med.Chem.
Header	Hydrolase
Released	2018-10-09
Resolution	3.000
CATH Insert Date	03 Feb, 2019

PDB Images (57)

6huq

PDB 6huq

6huqa

PDB Chain 6huqa

6huqA

PDB Chain 6huqA

6huqb

PDB Chain 6huqb

6huqB

PDB Chain 6huqB

6huqC

PDB Chain 6huqC

6huqD

PDB Chain 6huqD

6huqE

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6huqF

PDB Chain 6huqF

6huqG

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6huqH

PDB Chain 6huqH

6huqI

PDB Chain 6huqI

6huqJ

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6huqK

PDB Chain 6huqK

6huqL

PDB Chain 6huqL

6huqM

PDB Chain 6huqM

6huqN

PDB Chain 6huqN

6huqO

PDB Chain 6huqO

6huqP

PDB Chain 6huqP

6huqQ

PDB Chain 6huqQ

6huqR

PDB Chain 6huqR

6huqS

PDB Chain 6huqS

6huqT

PDB Chain 6huqT

6huqU

PDB Chain 6huqU

6huqV

PDB Chain 6huqV

6huqW

PDB Chain 6huqW

6huqX

PDB Chain 6huqX

6huqY

PDB Chain 6huqY

6huqZ

PDB Chain 6huqZ

6huqa00

CATH Domain 6huqa00

6huqA00

CATH Domain 6huqA00

6huqb00

CATH Domain 6huqb00

6huqB00

CATH Domain 6huqB00

6huqC00

CATH Domain 6huqC00

6huqD00

CATH Domain 6huqD00

6huqE00

CATH Domain 6huqE00

6huqF00

CATH Domain 6huqF00

6huqG00

CATH Domain 6huqG00

6huqH00

CATH Domain 6huqH00

6huqI00

CATH Domain 6huqI00

6huqJ00

CATH Domain 6huqJ00

6huqK00

CATH Domain 6huqK00

6huqL00

CATH Domain 6huqL00

6huqM00

CATH Domain 6huqM00

6huqN00

CATH Domain 6huqN00

6huqO00

CATH Domain 6huqO00

6huqP00

CATH Domain 6huqP00

6huqQ00

CATH Domain 6huqQ00

6huqR00

CATH Domain 6huqR00

6huqS00

CATH Domain 6huqS00

6huqT00

CATH Domain 6huqT00

6huqU00

CATH Domain 6huqU00

6huqV00

CATH Domain 6huqV00

6huqW00

CATH Domain 6huqW00

6huqX00

CATH Domain 6huqX00

6huqY00

CATH Domain 6huqY00

6huqZ00

CATH Domain 6huqZ00

PDB Prints

PDB Chains (28)

Chain ID	Date inserted into CATH	CATH Status
a	03 Feb, 2019	Chopped
A	03 Feb, 2019	Chopped
b	03 Feb, 2019	Chopped
B	03 Feb, 2019	Chopped
C	03 Feb, 2019	Chopped
D	03 Feb, 2019	Chopped
E	03 Feb, 2019	Chopped
F	03 Feb, 2019	Chopped
G	03 Feb, 2019	Chopped
H	03 Feb, 2019	Chopped
I	03 Feb, 2019	Chopped
J	03 Feb, 2019	Chopped
K	03 Feb, 2019	Chopped
L	03 Feb, 2019	Chopped
M	03 Feb, 2019	Chopped
N	03 Feb, 2019	Chopped
O	03 Feb, 2019	Chopped
P	03 Feb, 2019	Chopped
Q	03 Feb, 2019	Chopped
R	03 Feb, 2019	Chopped
S	03 Feb, 2019	Chopped
T	03 Feb, 2019	Chopped
U	03 Feb, 2019	Chopped
V	03 Feb, 2019	Chopped
W	03 Feb, 2019	Chopped
X	03 Feb, 2019	Chopped
Y	03 Feb, 2019	Chopped
Z	03 Feb, 2019	Chopped

CATH Domains (28)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
6huqa00	04 Feb, 2019	3.60.20.10	Assigned
6huqA00	04 Feb, 2019	3.60.20.10	Assigned
6huqb00	04 Feb, 2019	3.60.20.10	Assigned
6huqB00	04 Feb, 2019	3.60.20.10	Assigned
6huqC00	04 Feb, 2019	3.60.20.10	Assigned
6huqD00	04 Feb, 2019	3.60.20.10	Assigned
6huqE00	04 Feb, 2019	3.60.20.10	Assigned
6huqF00	04 Feb, 2019	3.60.20.10	Assigned
6huqG00	04 Feb, 2019	3.60.20.10	Assigned
6huqH00	04 Feb, 2019	3.60.20.10	Assigned
6huqI00	04 Feb, 2019	3.60.20.10	Assigned
6huqJ00	04 Feb, 2019	3.60.20.10	Assigned
6huqK00	04 Feb, 2019	3.60.20.10	Assigned
6huqL00	04 Feb, 2019	3.60.20.10	Assigned
6huqM00	04 Feb, 2019	3.60.20.10	Assigned
6huqN00	04 Feb, 2019	3.60.20.10	Assigned
6huqO00	04 Feb, 2019	3.60.20.10	Assigned
6huqP00	04 Feb, 2019	3.60.20.10	Assigned
6huqQ00	04 Feb, 2019	3.60.20.10	Assigned
6huqR00	04 Feb, 2019	3.60.20.10	Assigned
6huqS00	04 Feb, 2019	3.60.20.10	Assigned
6huqT00	04 Feb, 2019	3.60.20.10	Assigned
6huqU00	04 Feb, 2019	3.60.20.10	Assigned
6huqV00	04 Feb, 2019	3.60.20.10	Assigned
6huqW00	04 Feb, 2019	3.60.20.10	Assigned
6huqX00	04 Feb, 2019	3.60.20.10	Assigned
6huqY00	04 Feb, 2019	3.60.20.10	Assigned
6huqZ00	04 Feb, 2019	3.60.20.10	Assigned

UniProtKB Entries (28)

Accession	Gene ID	Taxon	Description
P40302	PSA6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-6
P22141	PSB4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-4
P25451	PSB3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-3
P21243	PSA1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-1
P22141	PSB4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-4
P38624	PSB1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-1
P23638	PSA3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-3
P25451	PSB3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-3
P21243	PSA1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-1
P30656	PSB5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-5
P23639	PSA2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-2
Q99436	PSB7_HUMAN	Homo sapiens	Proteasome subunit beta type-7
P23724	PSB6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-6
P23724	PSB6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-6
P30657	PSB7_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-7
Q99436	PSB7_HUMAN	Homo sapiens	Proteasome subunit beta type-7
P40303	PSA4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-4
P23638	PSA3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-3
P21242	PSA7_YEAST	Saccharomyces cerevisiae S288C	Probable proteasome subunit alpha type-7
P38624	PSB1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-1
P23639	PSA2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-2
P40303	PSA4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-4
P40302	PSA6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-6
P30657	PSB7_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-7
P21242	PSA7_YEAST	Saccharomyces cerevisiae S288C	Probable proteasome subunit alpha type-7
P30656	PSB5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-5
P32379	PSA5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-5
P32379	PSA5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-5