PDB 6htp

PDB Information

PDB6HTP
MethodX-RAY DIFFRACTION
Host OrganismSaccharomyces cerevisiae S288c
Gene SourceHomo sapiens
Primary Citation
Structure-Based Design of Inhibitors Selective for Human Proteasome beta 2c or beta 2i Subunits.
Xin, B.T., Huber, E.M., de Bruin, G., Heinemeyer, W., Maurits, E., Espinal, C., Du, Y., Janssens, M., Weyburne, E.S., Kisselev, A.F., Florea, B.I., Driessen, C., van der Marel, G.A., Groll, M., Overkleeft, H.S.
J.Med.Chem.
HeaderHydrolase
Released2018-10-04
Resolution3.000
CATH Insert Date03 Feb, 2019

PDB Images (57)

PDB Prints

PDB Chains (28)

Chain ID Date inserted into CATH CATH Status
a 03 Feb, 2019 Chopped
A 03 Feb, 2019 Chopped
b 03 Feb, 2019 Chopped
B 03 Feb, 2019 Chopped
C 03 Feb, 2019 Chopped
D 03 Feb, 2019 Chopped
E 03 Feb, 2019 Chopped
F 03 Feb, 2019 Chopped
G 03 Feb, 2019 Chopped
H 03 Feb, 2019 Chopped
I 03 Feb, 2019 Chopped
J 03 Feb, 2019 Chopped
K 03 Feb, 2019 Chopped
L 03 Feb, 2019 Chopped
M 03 Feb, 2019 Chopped
N 03 Feb, 2019 Chopped
O 03 Feb, 2019 Chopped
P 03 Feb, 2019 Chopped
Q 03 Feb, 2019 Chopped
R 03 Feb, 2019 Chopped
S 03 Feb, 2019 Chopped
T 03 Feb, 2019 Chopped
U 03 Feb, 2019 Chopped
V 03 Feb, 2019 Chopped
W 03 Feb, 2019 Chopped
X 03 Feb, 2019 Chopped
Y 03 Feb, 2019 Chopped
Z 03 Feb, 2019 Chopped

CATH Domains (28)

Domain ID Date inserted into CATH Superfamily CATH Status
6htpa00 04 Feb, 2019 3.60.20.10 Assigned
6htpA00 04 Feb, 2019 3.60.20.10 Assigned
6htpb00 04 Feb, 2019 3.60.20.10 Assigned
6htpB00 04 Feb, 2019 3.60.20.10 Assigned
6htpC00 04 Feb, 2019 3.60.20.10 Assigned
6htpD00 04 Feb, 2019 3.60.20.10 Assigned
6htpE00 04 Feb, 2019 3.60.20.10 Assigned
6htpF00 04 Feb, 2019 3.60.20.10 Assigned
6htpG00 04 Feb, 2019 3.60.20.10 Assigned
6htpH00 04 Feb, 2019 3.60.20.10 Assigned
6htpI00 04 Feb, 2019 3.60.20.10 Assigned
6htpJ00 04 Feb, 2019 3.60.20.10 Assigned
6htpK00 04 Feb, 2019 3.60.20.10 Assigned
6htpL00 04 Feb, 2019 3.60.20.10 Assigned
6htpM00 04 Feb, 2019 3.60.20.10 Assigned
6htpN00 04 Feb, 2019 3.60.20.10 Assigned
6htpO00 04 Feb, 2019 3.60.20.10 Assigned
6htpP00 04 Feb, 2019 3.60.20.10 Assigned
6htpQ00 04 Feb, 2019 3.60.20.10 Assigned
6htpR00 04 Feb, 2019 3.60.20.10 Assigned
6htpS00 04 Feb, 2019 3.60.20.10 Assigned
6htpT00 04 Feb, 2019 3.60.20.10 Assigned
6htpU00 04 Feb, 2019 3.60.20.10 Assigned
6htpV00 04 Feb, 2019 3.60.20.10 Assigned
6htpW00 04 Feb, 2019 3.60.20.10 Assigned
6htpX00 04 Feb, 2019 3.60.20.10 Assigned
6htpY00 04 Feb, 2019 3.60.20.10 Assigned
6htpZ00 04 Feb, 2019 3.60.20.10 Assigned

UniProtKB Entries (28)

Accession Gene ID Taxon Description
P23638 PSA3_YEAST Saccharomyces cerevisiae S288C Proteasome subunit alpha type-3
P21243 PSA1_YEAST Saccharomyces cerevisiae S288C Proteasome subunit alpha type-1
P32379 PSA5_YEAST Saccharomyces cerevisiae S288C Proteasome subunit alpha type-5
P23639 PSA2_YEAST Saccharomyces cerevisiae S288C Proteasome subunit alpha type-2
P23724 PSB6_YEAST Saccharomyces cerevisiae S288C Proteasome subunit beta type-6
P21242 PSA7_YEAST Saccharomyces cerevisiae S288C Probable proteasome subunit alpha type-7
P21242 PSA7_YEAST Saccharomyces cerevisiae S288C Probable proteasome subunit alpha type-7
P38624 PSB1_YEAST Saccharomyces cerevisiae S288C Proteasome subunit beta type-1
P23639 PSA2_YEAST Saccharomyces cerevisiae S288C Proteasome subunit alpha type-2
P23638 PSA3_YEAST Saccharomyces cerevisiae S288C Proteasome subunit alpha type-3
P25451 PSB3_YEAST Saccharomyces cerevisiae S288C Proteasome subunit beta type-3
P30656 PSB5_YEAST Saccharomyces cerevisiae S288C Proteasome subunit beta type-5
P21243 PSA1_YEAST Saccharomyces cerevisiae S288C Proteasome subunit alpha type-1
P38624 PSB1_YEAST Saccharomyces cerevisiae S288C Proteasome subunit beta type-1
Q99436 PSB7_HUMAN Homo sapiens Proteasome subunit beta type-7
Q99436 PSB7_HUMAN Homo sapiens Proteasome subunit beta type-7
P40303 PSA4_YEAST Saccharomyces cerevisiae S288C Proteasome subunit alpha type-4
P23724 PSB6_YEAST Saccharomyces cerevisiae S288C Proteasome subunit beta type-6
P40302 PSA6_YEAST Saccharomyces cerevisiae S288C Proteasome subunit alpha type-6
P30657 PSB7_YEAST Saccharomyces cerevisiae S288C Proteasome subunit beta type-7
P40303 PSA4_YEAST Saccharomyces cerevisiae S288C Proteasome subunit alpha type-4
P40302 PSA6_YEAST Saccharomyces cerevisiae S288C Proteasome subunit alpha type-6
P30657 PSB7_YEAST Saccharomyces cerevisiae S288C Proteasome subunit beta type-7
P22141 PSB4_YEAST Saccharomyces cerevisiae S288C Proteasome subunit beta type-4
P30656 PSB5_YEAST Saccharomyces cerevisiae S288C Proteasome subunit beta type-5
P32379 PSA5_YEAST Saccharomyces cerevisiae S288C Proteasome subunit alpha type-5
P25451 PSB3_YEAST Saccharomyces cerevisiae S288C Proteasome subunit beta type-3
P22141 PSB4_YEAST Saccharomyces cerevisiae S288C Proteasome subunit beta type-4