PDB 6htb

PDB Links
Overview

PDB Information

PDB	6HTB
Method	X-RAY DIFFRACTION
Host Organism	Saccharomyces cerevisiae S288c
Gene Source	Homo sapiens
Primary Citation	Structure-Based Design of Inhibitors Selective for Human Proteasome beta 2c or beta 2i Subunits. Xin, B.T., Huber, E.M., de Bruin, G., Heinemeyer, W., Maurits, E., Espinal, C., Du, Y., Janssens, M., Weyburne, E.S., Kisselev, A.F., Florea, B.I., Driessen, C., van der Marel, G.A., Groll, M., Overkleeft, H.S. J.Med.Chem.
Header	Hydrolase
Released	2018-10-03
Resolution	2.700
CATH Insert Date	03 Feb, 2019

PDB Images (57)

6htb

PDB 6htb

6htba

PDB Chain 6htba

6htbA

PDB Chain 6htbA

6htbb

PDB Chain 6htbb

6htbB

PDB Chain 6htbB

6htbC

PDB Chain 6htbC

6htbD

PDB Chain 6htbD

6htbE

PDB Chain 6htbE

6htbF

PDB Chain 6htbF

6htbG

PDB Chain 6htbG

6htbH

PDB Chain 6htbH

6htbI

PDB Chain 6htbI

6htbJ

PDB Chain 6htbJ

6htbK

PDB Chain 6htbK

6htbL

PDB Chain 6htbL

6htbM

PDB Chain 6htbM

6htbN

PDB Chain 6htbN

6htbO

PDB Chain 6htbO

6htbP

PDB Chain 6htbP

6htbQ

PDB Chain 6htbQ

6htbR

PDB Chain 6htbR

6htbS

PDB Chain 6htbS

6htbT

PDB Chain 6htbT

6htbU

PDB Chain 6htbU

6htbV

PDB Chain 6htbV

6htbW

PDB Chain 6htbW

6htbX

PDB Chain 6htbX

6htbY

PDB Chain 6htbY

6htbZ

PDB Chain 6htbZ

6htba00

CATH Domain 6htba00

6htbA00

CATH Domain 6htbA00

6htbb00

CATH Domain 6htbb00

6htbB00

CATH Domain 6htbB00

6htbC00

CATH Domain 6htbC00

6htbD00

CATH Domain 6htbD00

6htbE00

CATH Domain 6htbE00

6htbF00

CATH Domain 6htbF00

6htbG00

CATH Domain 6htbG00

6htbH00

CATH Domain 6htbH00

6htbI00

CATH Domain 6htbI00

6htbJ00

CATH Domain 6htbJ00

6htbK00

CATH Domain 6htbK00

6htbL00

CATH Domain 6htbL00

6htbM00

CATH Domain 6htbM00

6htbN00

CATH Domain 6htbN00

6htbO00

CATH Domain 6htbO00

6htbP00

CATH Domain 6htbP00

6htbQ00

CATH Domain 6htbQ00

6htbR00

CATH Domain 6htbR00

6htbS00

CATH Domain 6htbS00

6htbT00

CATH Domain 6htbT00

6htbU00

CATH Domain 6htbU00

6htbV00

CATH Domain 6htbV00

6htbW00

CATH Domain 6htbW00

6htbX00

CATH Domain 6htbX00

6htbY00

CATH Domain 6htbY00

6htbZ00

CATH Domain 6htbZ00

PDB Prints

PDB Chains (28)

Chain ID	Date inserted into CATH	CATH Status
a	03 Feb, 2019	Chopped
A	03 Feb, 2019	Chopped
b	03 Feb, 2019	Chopped
B	03 Feb, 2019	Chopped
C	03 Feb, 2019	Chopped
D	03 Feb, 2019	Chopped
E	03 Feb, 2019	Chopped
F	03 Feb, 2019	Chopped
G	03 Feb, 2019	Chopped
H	03 Feb, 2019	Chopped
I	03 Feb, 2019	Chopped
J	03 Feb, 2019	Chopped
K	03 Feb, 2019	Chopped
L	03 Feb, 2019	Chopped
M	03 Feb, 2019	Chopped
N	03 Feb, 2019	Chopped
O	03 Feb, 2019	Chopped
P	03 Feb, 2019	Chopped
Q	03 Feb, 2019	Chopped
R	03 Feb, 2019	Chopped
S	03 Feb, 2019	Chopped
T	03 Feb, 2019	Chopped
U	03 Feb, 2019	Chopped
V	03 Feb, 2019	Chopped
W	03 Feb, 2019	Chopped
X	03 Feb, 2019	Chopped
Y	03 Feb, 2019	Chopped
Z	03 Feb, 2019	Chopped

CATH Domains (28)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
6htba00	04 Feb, 2019	3.60.20.10	Assigned
6htbA00	04 Feb, 2019	3.60.20.10	Assigned
6htbb00	04 Feb, 2019	3.60.20.10	Assigned
6htbB00	04 Feb, 2019	3.60.20.10	Assigned
6htbC00	04 Feb, 2019	3.60.20.10	Assigned
6htbD00	04 Feb, 2019	3.60.20.10	Assigned
6htbE00	04 Feb, 2019	3.60.20.10	Assigned
6htbF00	04 Feb, 2019	3.60.20.10	Assigned
6htbG00	04 Feb, 2019	3.60.20.10	Assigned
6htbH00	04 Feb, 2019	3.60.20.10	Assigned
6htbI00	04 Feb, 2019	3.60.20.10	Assigned
6htbJ00	04 Feb, 2019	3.60.20.10	Assigned
6htbK00	04 Feb, 2019	3.60.20.10	Assigned
6htbL00	04 Feb, 2019	3.60.20.10	Assigned
6htbM00	04 Feb, 2019	3.60.20.10	Assigned
6htbN00	04 Feb, 2019	3.60.20.10	Assigned
6htbO00	04 Feb, 2019	3.60.20.10	Assigned
6htbP00	04 Feb, 2019	3.60.20.10	Assigned
6htbQ00	04 Feb, 2019	3.60.20.10	Assigned
6htbR00	04 Feb, 2019	3.60.20.10	Assigned
6htbS00	04 Feb, 2019	3.60.20.10	Assigned
6htbT00	04 Feb, 2019	3.60.20.10	Assigned
6htbU00	04 Feb, 2019	3.60.20.10	Assigned
6htbV00	04 Feb, 2019	3.60.20.10	Assigned
6htbW00	04 Feb, 2019	3.60.20.10	Assigned
6htbX00	04 Feb, 2019	3.60.20.10	Assigned
6htbY00	04 Feb, 2019	3.60.20.10	Assigned
6htbZ00	04 Feb, 2019	3.60.20.10	Assigned

UniProtKB Entries (28)

Accession	Gene ID	Taxon	Description
Q99436	PSB7_HUMAN	Homo sapiens	Proteasome subunit beta type-7
P23638	PSA3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-3
P25451	PSB3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-3
P22141	PSB4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-4
P22141	PSB4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-4
P38624	PSB1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-1
P32379	PSA5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-5
P40303	PSA4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-4
P30657	PSB7_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-7
P38624	PSB1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-1
P23638	PSA3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-3
P21242	PSA7_YEAST	Saccharomyces cerevisiae S288C	Probable proteasome subunit alpha type-7
P30656	PSB5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-5
P23639	PSA2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-2
P40302	PSA6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-6
P23724	PSB6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-6
P21243	PSA1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-1
P32379	PSA5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-5
P23724	PSB6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-6
P30657	PSB7_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-7
P21242	PSA7_YEAST	Saccharomyces cerevisiae S288C	Probable proteasome subunit alpha type-7
P23639	PSA2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-2
Q99436	PSB7_HUMAN	Homo sapiens	Proteasome subunit beta type-7
P21243	PSA1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-1
P40303	PSA4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-4
P25451	PSB3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-3
P40302	PSA6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-6
P30656	PSB5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-5