PDB 6h4p

PDB Information

PDB6H4P
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli BL21(DE3)
Gene SourceHomo sapiens
Primary Citation
C8-substituted pyrido[3,4-d]pyrimidin-4(3H)-ones: Studies towards the identification of potent, cell penetrant Jumonji C domain containing histone lysine demethylase 4 subfamily (KDM4) inhibitors, compound profiling in cell-based target engagement assays.
Le Bihan, Y.V., Lanigan, R.M., Atrash, B., McLaughlin, M.G., Velupillai, S., Malcolm, A.G., England, K.S., Ruda, G.F., Mok, N.Y., Tumber, A., Tomlin, K., Saville, H., Shehu, E., McAndrew, C., Carmichael, L., Bennett, J.M., Jeganathan, F., Eve, P., Donovan, A., Hayes, A., Wood, F., Raynaud, F.I., Fedorov, O., Brennan, P.E., Burke, R., van Montfort, R.L.M., Rossanese, O.W., Blagg, J., Bavetsias, V.
Eur.J.Med.Chem.
HeaderOxidoreductase
Released2018-07-23
Resolution2.190
CATH Insert Date16 Jun, 2019

PDB Images (5)

PDB Prints

PDB Chains (4)

Chain ID Date inserted into CATH CATH Status
A 16 Jun, 2019 New
B 16 Jun, 2019 New
C 16 Jun, 2019 New
D 16 Jun, 2019 New

CATH Domains (0)

Domain ID Date inserted into CATH Superfamily CATH Status

UniProtKB Entries (0)

Accession Gene ID Taxon Description