PDB Information

PDB6H3K
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Introduction of a Methyl Group Curbs Metabolism of Pyrido[3,4- d]pyrimidine Monopolar Spindle 1 (MPS1) Inhibitors and Enables the Discovery of the Phase 1 Clinical Candidate N2-(2-Ethoxy-4-(4-methyl-4 H-1,2,4-triazol-3-yl)phenyl)-6-methyl- N8-neopentylpyrido[3,4- d]pyrimidine-2,8-diamine (BOS172722).
Woodward, H.L., Innocenti, P., Cheung, K.J., Hayes, A., Roberts, J., Henley, A.T., Faisal, A., Mak, G.W., Box, G., Westwood, I.M., Cronin, N., Carter, M., Valenti, M., De Haven Brandon, A., O'Fee, L., Saville, H., Schmitt, J., Burke, R., Broccatelli, F., van Montfort, R.L.M., Raynaud, F.I., Eccles, S.A., Linardopoulos, S., Blagg, J., Hoelder, S.
J. Med. Chem.
HeaderTransferase
Released2018-07-19
Resolution2.480
CATH Insert Date23 Sep, 2018

PDB Images (4)

PDB Prints

PDB Chains (1)

Chain ID Date inserted into CATH CATH Status
A 23 Sep, 2018 Chopped

CATH Domains (2)

Domain ID Date inserted into CATH Superfamily CATH Status
6h3kA01 24 Sep, 2018 3.30.200.20 Assigned
6h3kA02 24 Sep, 2018 1.10.510.10 Assigned

UniProtKB Entries (1)

Accession Gene ID Taxon Description
P33981 TTK_HUMAN Homo sapiens Dual specificity protein kinase TTK