PDB 6epm

PDB Information

PDB6EPM
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS-SOS1 interaction.
Hillig, R.C., Sautier, B., Schroeder, J., Moosmayer, D., Hilpmann, A., Stegmann, C.M., Werbeck, N.D., Briem, H., Boemer, U., Weiske, J., Badock, V., Mastouri, J., Petersen, K., Siemeister, G., Kahmann, J.D., Wegener, D., Bohnke, N., Eis, K., Graham, K., Wortmann, L., von Nussbaum, F., Bader, B.
Proc. Natl. Acad. Sci. U.S.A.
HeaderSignaling Protein
Released2017-10-12
Resolution2.500
CATH Insert Date10 Feb, 2019

PDB Images (6)

PDB Prints

PDB Chains (2)

Chain ID Date inserted into CATH CATH Status
R 10 Feb, 2019 Chopped
S 10 Feb, 2019 Chopped

CATH Domains (3)

Domain ID Date inserted into CATH Superfamily CATH Status
6epmR00 11 Feb, 2019 3.40.50.300 Assigned
6epmS01 11 Feb, 2019 1.20.870.10 Assigned
6epmS02 11 Feb, 2019 1.10.840.10 Assigned

UniProtKB Entries (2)

Accession Gene ID Taxon Description
Q07889 SOS1_HUMAN Homo sapiens Son of sevenless homolog 1
P01116 RASK_HUMAN Homo sapiens GTPase KRas
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