PDB 6e4u

PDB Information

PDB6E4U
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceRattus norvegicus
Primary Citation
Acyl Glucuronide Metabolites of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1 H-indole-3-carboxylic Acid (PF-06409577) and Related Indole-3-carboxylic Acid Derivatives are Direct Activators of Adenosine Monophosphate-Activated Protein Kinase (AMPK).
Ryder, T.F., Calabrese, M.F., Walker, G.S., Cameron, K.O., Reyes, A.R., Borzilleri, K.A., Delmore, J., Miller, R., Kurumbail, R.G., Ward, J., Kung, D.W., Brown, J.A., Edmonds, D.J., Eng, H., Wolford, A.C., Kalgutkar, A.S.
J. Med. Chem.
HeaderTransferase
Released2018-07-18
Resolution3.270
CATH Insert Date12 Aug, 2018

PDB Images (5)

PDB Prints

PDB Chains (3)

Chain ID Date inserted into CATH CATH Status
A 12 Aug, 2018 Holding pen
B 12 Aug, 2018 Holding pen
C 12 Aug, 2018 Chopped

CATH Domains (1)

Domain ID Date inserted into CATH Superfamily CATH Status
6e4uC00 13 Aug, 2018 Holding pen

UniProtKB Entries (3)

Accession Gene ID Taxon Description
P54645 AAPK1_RAT Rattus norvegicus 5'-AMP-activated protein kinase catalytic subunit alpha-1
P80386 AAKB1_RAT Rattus norvegicus 5'-AMP-activated protein kinase subunit beta-1
P80385 AAKG1_RAT Rattus norvegicus 5'-AMP-activated protein kinase subunit gamma-1