PDB 6dhc

PDB Information

PDB6DHC
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Design, synthesis, X-ray studies, and biological evaluation of novel BACE1 inhibitors with bicyclic isoxazoline carboxamides as the P3 ligand.
Ghosh, A.K., Ghosh, K., Brindisi, M., Lendy, E.K., Yen, Y.C., Kumaragurubaran, N., Huang, X., Tang, J., Mesecar, A.D.
Bioorg. Med. Chem. Lett.
HeaderHydrolase
Released2018-05-19
Resolution2.850
CATH Insert Date29 Jul, 2018

PDB Images (10)

PDB Prints

PDB Chains (3)

Chain ID Date inserted into CATH CATH Status
A 29 Jul, 2018 Chopped
B 29 Jul, 2018 Chopped
C 29 Jul, 2018 Chopped

CATH Domains (6)

Domain ID Date inserted into CATH Superfamily CATH Status
6dhcA01 30 Jul, 2018 2.40.70.10 Assigned
6dhcA02 30 Jul, 2018 2.40.70.10 Assigned
6dhcB01 30 Jul, 2018 2.40.70.10 Assigned
6dhcB02 30 Jul, 2018 2.40.70.10 Assigned
6dhcC01 30 Jul, 2018 2.40.70.10 Assigned
6dhcC02 30 Jul, 2018 2.40.70.10 Assigned

UniProtKB Entries (3)

Accession Gene ID Taxon Description
P56817 BACE1_HUMAN Homo sapiens Beta-secretase 1
P56817 BACE1_HUMAN Homo sapiens Beta-secretase 1
P56817 BACE1_HUMAN Homo sapiens Beta-secretase 1