PDB 6d5m

PDB Links
Overview

PDB Information

PDB	6D5M
Method	X-RAY DIFFRACTION
Host Organism	Escherichia coli
Gene Source	Homo sapiens
Primary Citation	Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RAS. Hodges, T.R., Abbott, J.R., Little, A.J., Sarkar, D., Salovich, J.M., Howes, J.E., Akan, D.T., Sai, J., Arnold, A.L., Browning, C., Burns, M.C., Sobolik, T., Sun, Q., Beesetty, Y., Coker, J.A., Scharn, D., Stadtmueller, H., Rossanese, O.W., Phan, J., Waterson, A.G., McConnell, D.B., Fesik, S.W. J. Med. Chem.
Header	Signaling Protein
Released	2018-04-19
Resolution	2.080
CATH Insert Date	23 Sep, 2018

PDB Images (8)

Image of CATH 6d5m

6d5m

PDB 6d5m

Image of CATH 6d5mQ

6d5mQ

PDB Chain 6d5mQ

Image of CATH 6d5mR

6d5mR

PDB Chain 6d5mR

Image of CATH 6d5mS

6d5mS

PDB Chain 6d5mS

Image of CATH 6d5mQ00

6d5mQ00

CATH Domain 6d5mQ00

Image of CATH 6d5mR00

6d5mR00

CATH Domain 6d5mR00

Image of CATH 6d5mS01

6d5mS01

CATH Domain 6d5mS01

Image of CATH 6d5mS02

6d5mS02

CATH Domain 6d5mS02

PDB Prints

PDB Chains (3)

Chain ID	Date inserted into CATH	CATH Status
Q	23 Sep, 2018	Chopped
R	23 Sep, 2018	Chopped
S	23 Sep, 2018	Chopped

CATH Domains (4)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
6d5mQ00	24 Sep, 2018	3.40.50.300	Assigned
6d5mR00	24 Sep, 2018	3.40.50.300	Assigned
6d5mS01	24 Sep, 2018	1.20.870.10	Assigned
6d5mS02	24 Sep, 2018	1.10.840.10	Assigned

UniProtKB Entries (3)

Accession	Gene ID	Taxon	Description
Q07889	SOS1_HUMAN	Homo sapiens	Son of sevenless homolog 1
P01112	RASH_HUMAN	Homo sapiens	GTPase HRas
P01112	RASH_HUMAN	Homo sapiens	GTPase HRas