PDB 6cup

PDB Links
Overview

PDB Information

PDB	6CUP
Method	X-RAY DIFFRACTION
Host Organism	Escherichia coli
Gene Source	Homo sapiens
Primary Citation	Discovery of Quinazolines That Activate SOS1-Mediated Nucleotide Exchange on RAS. Abbott, J.R., Patel, P.A., Howes, J.E., Akan, D.T., Kennedy, J.P., Burns, M.C., Browning, C.F., Sun, Q., Rossanese, O.W., Phan, J., Waterson, A.G., Fesik, S.W. ACS Med Chem Lett
Header	Signaling Protein
Released	2018-03-26
Resolution	1.830
CATH Insert Date	10 Feb, 2019

PDB Images (8)

Image of CATH 6cup

6cup

PDB 6cup

Image of CATH 6cupA

6cupA

PDB Chain 6cupA

Image of CATH 6cupB

6cupB

PDB Chain 6cupB

Image of CATH 6cupC

6cupC

PDB Chain 6cupC

Image of CATH 6cupA00

6cupA00

CATH Domain 6cupA00

Image of CATH 6cupB01

6cupB01

CATH Domain 6cupB01

Image of CATH 6cupB02

6cupB02

CATH Domain 6cupB02

Image of CATH 6cupC00

6cupC00

CATH Domain 6cupC00

PDB Prints

PDB Chains (3)

Chain ID	Date inserted into CATH	CATH Status
A	10 Feb, 2019	Chopped
B	10 Feb, 2019	Chopped
C	10 Feb, 2019	Chopped

CATH Domains (4)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
6cupA00	11 Feb, 2019	3.40.50.300	Assigned
6cupB01	11 Feb, 2019	1.20.870.10	Assigned
6cupB02	11 Feb, 2019	1.10.840.10	Assigned
6cupC00	11 Feb, 2019	3.40.50.300	Assigned

UniProtKB Entries (3)

Accession	Gene ID	Taxon	Description
P01112	RASH_HUMAN	Homo sapiens	GTPase HRas
P01112	RASH_HUMAN	Homo sapiens	GTPase HRas
Q07889	SOS1_HUMAN	Homo sapiens	Son of sevenless homolog 1