PDB Information

PDB6CJW
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Structure-based Design of Pyridone-Aminal eFT508 Targeting Dysregulated Translation by Selective Mitogen-activated Protein Kinase Interacting Kinases 1 and 2 (MNK1/2) Inhibition.
Reich, S.H., Sprengeler, P.A., Chiang, G.G., Appleman, J.R., Chen, J., Clarine, J., Eam, B., Ernst, J.T., Han, Q., Goel, V.K., Han, E.Z.R., Huang, V., Hung, I.N.J., Jemison, A., Jessen, K.A., Molter, J., Murphy, D., Neal, M., Parker, G.S., Shaghafi, M., Sperry, S., Staunton, J., Stumpf, C.R., Thompson, P.A., Tran, C., Webber, S.E., Wegerski, C.J., Zheng, H., Webster, K.R.
J. Med. Chem.
HeaderTransferase/Transferase Inhibitor
Released2018-02-27
Resolution3.380
CATH Insert Date03 Jun, 2018

PDB Images (4)

PDB Prints

PDB Chains (1)

Chain ID Date inserted into CATH CATH Status
A 03 Jun, 2018 Chopped

CATH Domains (2)

Domain ID Date inserted into CATH Superfamily CATH Status
6cjwA01 29 Jun, 2018 3.30.200.20 Assigned
6cjwA02 29 Jun, 2018 1.10.510.10 Assigned

UniProtKB Entries (1)

Accession Gene ID Taxon Description
Q9HBH9 MKNK2_HUMAN Homo sapiens MAP kinase-interacting serine/threonine-protein kinase 2
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