PDB Information

PDB6C1S
MethodX-RAY DIFFRACTION
Host OrganismSpodoptera frugiperda
Gene SourceHomo sapiens
Primary Citation
Design and Synthesis of a Novel Series of Orally Bioavailable, CNS-Penetrant, Isoform Selective Phosphoinositide 3-Kinase gamma (PI3K gamma ) Inhibitors with Potential for the Treatment of Multiple Sclerosis (MS).
Come, J.H., Collier, P.N., Henderson, J.A., Pierce, A.C., Davies, R.J., Le Tiran, A., O'Dowd, H., Bandarage, U.K., Cao, J., Deininger, D., Grey, R., Krueger, E.B., Lowe, D.B., Liang, J., Liao, Y., Messersmith, D., Nanthakumar, S., Sizensky, E., Wang, J., Xu, J., Chin, E.Y., Damagnez, V., Doran, J.D., Dworakowski, W., Griffith, J.P., Jacobs, M.D., Khare-Pandit, S., Mahajan, S., Moody, C.S., Aronov, A.M.
J. Med. Chem.
HeaderTransferase/Transferase Inhibitor
Released2018-01-05
Resolution2.310
CATH Insert Date06 Jul, 2018

PDB Images (7)

PDB Prints

PDB Chains (1)

Chain ID Date inserted into CATH CATH Status
A 06 Jul, 2018 Chopped

CATH Domains (5)

Domain ID Date inserted into CATH Superfamily CATH Status
6c1sA01 19 Jul, 2018 3.10.20.90 Assigned
6c1sA02 19 Jul, 2018 2.60.40.150 Assigned
6c1sA03 19 Jul, 2018 1.25.40.70 Assigned
6c1sA04 19 Jul, 2018 3.30.1010.10 Assigned
6c1sA05 19 Jul, 2018 1.10.1070.11 Assigned

UniProtKB Entries (1)

Accession Gene ID Taxon Description
P48736 PK3CG_HUMAN Homo sapiens Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform