PDB 6bfx

PDB Information

PDB6BFX
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Optimization of Hydroxyethylamine Transition State Isosteres as Aspartic Protease Inhibitors by Exploiting Conformational Preferences.
Bueno, A.B., Agejas, J., Broughton, H., Dally, R., Durham, T.B., Espinosa, J.F., Gonzalez, R., Hahn, P.J., Marcos, A., Rodriguez, R., Sanz, G., Soriano, J.F., Timm, D., Vidal, P., Yang, H.C., McCarthy, J.R.
J. Med. Chem.
HeaderHydrolase/Hydrolase Inhibitor
Released2017-10-27
Resolution1.990
CATH Insert Date17 Dec, 2017

PDB Images (7)

PDB Prints

PDB Chains (2)

Chain ID Date inserted into CATH CATH Status
A 17 Dec, 2017 Chopped
B 17 Dec, 2017 Chopped

CATH Domains (4)

Domain ID Date inserted into CATH Superfamily CATH Status
6bfxA01 24 Dec, 2017 2.40.70.10 Assigned
6bfxA02 24 Dec, 2017 2.40.70.10 Assigned
6bfxB01 24 Dec, 2017 2.40.70.10 Assigned
6bfxB02 24 Dec, 2017 2.40.70.10 Assigned

UniProtKB Entries (2)

Accession Gene ID Taxon Description
P56817 BACE1_HUMAN Homo sapiens Beta-secretase 1
P56817 BACE1_HUMAN Homo sapiens Beta-secretase 1