PDB 6acb

PDB Information

PDB6ACB
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli BL21
Gene SourceHomo sapiens
Primary Citation
Optimization of Chromeno[2,3- c]pyrrol-9(2 H)-ones as Highly Potent, Selective, and Orally Bioavailable PDE5 Inhibitors: Structure-Activity Relationship, X-ray Crystal Structure, and Pharmacodynamic Effect on Pulmonary Arterial Hypertension.
Wu, D., Huang, Y., Chen, Y., Huang, Y.Y., Geng, H., Zhang, T., Zhang, C., Li, Z., Guo, L., Chen, J., Luo, H.B.
J. Med. Chem.
HeaderHydrolase/Hydrolase Inhibitor
Released2018-07-26
Resolution2.800
CATH Insert Date23 Sep, 2018

PDB Images (3)

PDB Prints

PDB Chains (1)

Chain ID Date inserted into CATH CATH Status
A 23 Sep, 2018 Chopped

CATH Domains (1)

Domain ID Date inserted into CATH Superfamily CATH Status
6acbA00 24 Sep, 2018 1.10.1300.10 Assigned

UniProtKB Entries (1)

Accession Gene ID Taxon Description
O76074 PDE5A_HUMAN Homo sapiens cGMP-specific 3',5'-cyclic phosphodiesterase
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