PDB Information

PDB5TTV
MethodX-RAY DIFFRACTION
Host OrganismSpodoptera frugiperda
Gene SourceHomo sapiens
Primary Citation
Design of a Janus Kinase 3 (JAK3) Specific Inhibitor 1-((2S,5R)-5-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one (PF-06651600) Allowing for the Interrogation of JAK3 Signaling in Humans.
Thorarensen, A., Dowty, M.E., Banker, M.E., Juba, B., Jussif, J., Lin, T., Vincent, F., Czerwinski, R.M., Casimiro-Garcia, A., Unwalla, R., Trujillo, J.I., Liang, S., Balbo, P., Che, Y., Gilbert, A.M., Brown, M.F., Hayward, M., Montgomery, J., Leung, L., Yang, X., Soucy, S., Hegen, M., Coe, J., Langille, J., Vajdos, F., Chrencik, J., Telliez, J.B.
J. Med. Chem.
HeaderTransferase/Transferase Inhibitor
Released2016-11-04
Resolution1.930
CATH Insert Date07 May, 2017

PDB Images (4)

PDB Prints

PDB Chains (1)

Chain ID Date inserted into CATH CATH Status
A 08 May, 2017 Chopped

CATH Domains (2)

Domain ID Date inserted into CATH Superfamily CATH Status
5ttvA01 22 May, 2017 3.30.200.20 Assigned
5ttvA02 22 May, 2017 1.10.510.10 Assigned

UniProtKB Entries (1)

Accession Gene ID Taxon Description
P52333 JAK3_HUMAN Homo sapiens Tyrosine-protein kinase JAK3
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