PDB Information

PDB5TP9
MethodX-RAY DIFFRACTION
Host OrganismSpodoptera frugiperda
Gene SourceHomo sapiens
Primary Citation
GluN2A-Selective Pyridopyrimidinone Series of NMDAR Positive Allosteric Modulators with an Improved in Vivo Profile.
Villemure, E., Volgraf, M., Jiang, Y., Wu, G., Ly, C.Q., Yuen, P.W., Lu, A., Luo, X., Liu, M., Zhang, S., Lupardus, P.J., Wallweber, H.J., Liederer, B.M., Deshmukh, G., Plise, E., Tay, S., Wang, T.M., Hanson, J.E., Hackos, D.H., Scearce-Levie, K., Schwarz, J.B., Sellers, B.D.
ACS Med Chem Lett
HeaderTransport Protein
Released2016-10-20
Resolution2.400
CATH Insert Date04 Dec, 2016

PDB Images (7)

PDB Prints

PDB Chains (2)

Chain ID Date inserted into CATH CATH Status
A 05 Dec, 2016 Chopped
B 05 Dec, 2016 Chopped

CATH Domains (4)

Domain ID Date inserted into CATH Superfamily CATH Status
5tp9A01 10 Dec, 2016 3.40.190.10 Assigned
5tp9A02 10 Dec, 2016 3.40.190.10 Assigned
5tp9B01 10 Dec, 2016 3.40.190.10 Assigned
5tp9B02 10 Dec, 2016 3.40.190.10 Assigned

UniProtKB Entries (2)

Accession Gene ID Taxon Description
Q12879 NMDE1_HUMAN Homo sapiens Glutamate receptor ionotropic, NMDA 2A
Q05586 NMDZ1_HUMAN Homo sapiens Glutamate receptor ionotropic, NMDA 1