Potent, Orally Bioavailable and Efficacious Macrocyclic Inhibitors of Factor XIa. Discovery of Pyridine-Based Macrocycles Possessing Phenylazole Carboxamide P1 Groups.
Corte, J.R., Pinto, D.J.P., Fang, T., Osuna, H., Yang, W., Wang, Y., Lai, A., Clark, C., Sun, J.H., Rampulla, R.A., Mathur, A., Kaspady, M., Neithnadka, P.R., Li, Y.X., Rossi, K.A., Myers, J.E., Sheriff, S., Lou, Z., Harper, T.W., Huang, C.S., Zheng, J.J., Bozarth, J.M., Wu, Y., Wong, P.C., Crain, E., Seiffert, D.A., Luettgen, J.M., Lam, P., Wexler, R.R., Ewing, W.R.
J.Med.Chem.
