PDB 5nw0

PDB Information

PDB5NW0
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Group-Based Optimization of Potent and Cell-Active Inhibitors of the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase: Structure-Activity Relationships Leading to the Chemical Probe (2S,4R)-1-((S)-2-(1-Cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (VH298).
Soares, P., Gadd, M.S., Frost, J., Galdeano, C., Ellis, L., Epemolu, O., Rocha, S., Read, K.D., Ciulli, A.
J. Med. Chem.
HeaderLigase
Released2017-05-04
Resolution2.300
CATH Insert Date14 Nov, 2017

PDB Images (29)

PDB Prints

PDB Chains (12)

Chain ID Date inserted into CATH CATH Status
A 14 Nov, 2017 Chopped
B 14 Nov, 2017 Chopped
C 14 Nov, 2017 Chopped
D 14 Nov, 2017 Chopped
E 14 Nov, 2017 Chopped
F 14 Nov, 2017 Chopped
G 14 Nov, 2017 Chopped
H 14 Nov, 2017 Chopped
I 14 Nov, 2017 Chopped
J 14 Nov, 2017 Chopped
K 14 Nov, 2017 Chopped
L 14 Nov, 2017 Chopped

CATH Domains (16)

Domain ID Date inserted into CATH Superfamily CATH Status
5nw0A00 10 Dec, 2017 3.10.20.90 Assigned
5nw0B00 10 Dec, 2017 3.30.710.10 Assigned
5nw0C01 10 Dec, 2017 2.60.40.780 Assigned
5nw0C02 10 Dec, 2017 1.10.750.10 Assigned
5nw0D00 10 Dec, 2017 3.10.20.90 Assigned
5nw0E00 10 Dec, 2017 3.30.710.10 Assigned
5nw0F01 10 Dec, 2017 2.60.40.780 Assigned
5nw0F02 10 Dec, 2017 1.10.750.10 Assigned
5nw0G00 10 Dec, 2017 3.10.20.90 Assigned
5nw0H00 10 Dec, 2017 3.30.710.10 Assigned
5nw0I01 10 Dec, 2017 2.60.40.780 Assigned
5nw0I02 10 Dec, 2017 1.10.750.10 Assigned
5nw0J00 10 Dec, 2017 3.10.20.90 Assigned
5nw0K00 10 Dec, 2017 3.30.710.10 Assigned
5nw0L01 10 Dec, 2017 2.60.40.780 Assigned
5nw0L02 10 Dec, 2017 1.10.750.10 Assigned

UniProtKB Entries (12)

Accession Gene ID Taxon Description
Q15369 ELOC_HUMAN Homo sapiens Elongin-C
Q15369 ELOC_HUMAN Homo sapiens Elongin-C
Q15370 ELOB_HUMAN Homo sapiens Elongin-B
Q15369 ELOC_HUMAN Homo sapiens Elongin-C
P40337 VHL_HUMAN Homo sapiens von Hippel-Lindau disease tumor suppressor
Q15370 ELOB_HUMAN Homo sapiens Elongin-B
P40337 VHL_HUMAN Homo sapiens von Hippel-Lindau disease tumor suppressor
Q15369 ELOC_HUMAN Homo sapiens Elongin-C
Q15370 ELOB_HUMAN Homo sapiens Elongin-B
P40337 VHL_HUMAN Homo sapiens von Hippel-Lindau disease tumor suppressor
P40337 VHL_HUMAN Homo sapiens von Hippel-Lindau disease tumor suppressor
Q15370 ELOB_HUMAN Homo sapiens Elongin-B