PDB 5nvz

PDB Information

PDB5NVZ
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Group-Based Optimization of Potent and Cell-Active Inhibitors of the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase: Structure-Activity Relationships Leading to the Chemical Probe (2S,4R)-1-((S)-2-(1-Cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (VH298).
Soares, P., Gadd, M.S., Frost, J., Galdeano, C., Ellis, L., Epemolu, O., Rocha, S., Read, K.D., Ciulli, A.
J. Med. Chem.
HeaderLigase
Released2017-05-04
Resolution2.700
CATH Insert Date14 Nov, 2017

PDB Images (29)

PDB Prints

PDB Chains (12)

Chain ID Date inserted into CATH CATH Status
A 14 Nov, 2017 Chopped
B 14 Nov, 2017 Chopped
C 14 Nov, 2017 Chopped
D 14 Nov, 2017 Chopped
E 14 Nov, 2017 Chopped
F 14 Nov, 2017 Chopped
G 14 Nov, 2017 Chopped
H 14 Nov, 2017 Chopped
I 14 Nov, 2017 Chopped
J 14 Nov, 2017 Chopped
K 14 Nov, 2017 Chopped
L 14 Nov, 2017 Chopped

CATH Domains (16)

Domain ID Date inserted into CATH Superfamily CATH Status
5nvzA00 10 Dec, 2017 3.10.20.90 Assigned
5nvzB00 10 Dec, 2017 3.30.710.10 Assigned
5nvzC01 10 Dec, 2017 2.60.40.780 Assigned
5nvzC02 10 Dec, 2017 1.10.750.10 Assigned
5nvzD00 10 Dec, 2017 3.10.20.90 Assigned
5nvzE00 10 Dec, 2017 3.30.710.10 Assigned
5nvzF01 10 Dec, 2017 2.60.40.780 Assigned
5nvzF02 10 Dec, 2017 1.10.750.10 Assigned
5nvzG00 10 Dec, 2017 3.10.20.90 Assigned
5nvzH00 10 Dec, 2017 3.30.710.10 Assigned
5nvzI01 10 Dec, 2017 2.60.40.780 Assigned
5nvzI02 10 Dec, 2017 1.10.750.10 Assigned
5nvzJ00 10 Dec, 2017 3.10.20.90 Assigned
5nvzK00 10 Dec, 2017 3.30.710.10 Assigned
5nvzL01 10 Dec, 2017 2.60.40.780 Assigned
5nvzL02 10 Dec, 2017 1.10.750.10 Assigned

UniProtKB Entries (12)

Accession Gene ID Taxon Description
Q15369 ELOC_HUMAN Homo sapiens Elongin-C
P40337 VHL_HUMAN Homo sapiens von Hippel-Lindau disease tumor suppressor
P40337 VHL_HUMAN Homo sapiens von Hippel-Lindau disease tumor suppressor
Q15370 ELOB_HUMAN Homo sapiens Elongin-B
Q15369 ELOC_HUMAN Homo sapiens Elongin-C
Q15370 ELOB_HUMAN Homo sapiens Elongin-B
P40337 VHL_HUMAN Homo sapiens von Hippel-Lindau disease tumor suppressor
P40337 VHL_HUMAN Homo sapiens von Hippel-Lindau disease tumor suppressor
Q15369 ELOC_HUMAN Homo sapiens Elongin-C
Q15370 ELOB_HUMAN Homo sapiens Elongin-B
Q15369 ELOC_HUMAN Homo sapiens Elongin-C
Q15370 ELOB_HUMAN Homo sapiens Elongin-B