PDB 5nvv

PDB Information

PDB5NVV
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Group-Based Optimization of Potent and Cell-Active Inhibitors of the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase: Structure-Activity Relationships Leading to the Chemical Probe (2S,4R)-1-((S)-2-(1-Cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (VH298).
Soares, P., Gadd, M.S., Frost, J., Galdeano, C., Ellis, L., Epemolu, O., Rocha, S., Read, K.D., Ciulli, A.
J. Med. Chem.
HeaderLigase
Released2017-05-04
Resolution2.100
CATH Insert Date14 Nov, 2017

PDB Images (29)

PDB Prints

PDB Chains (12)

Chain ID Date inserted into CATH CATH Status
A 14 Nov, 2017 Chopped
B 14 Nov, 2017 Chopped
C 14 Nov, 2017 Chopped
D 14 Nov, 2017 Chopped
E 14 Nov, 2017 Chopped
F 14 Nov, 2017 Chopped
G 14 Nov, 2017 Chopped
H 14 Nov, 2017 Chopped
I 14 Nov, 2017 Chopped
J 14 Nov, 2017 Chopped
K 14 Nov, 2017 Chopped
L 14 Nov, 2017 Chopped

CATH Domains (16)

Domain ID Date inserted into CATH Superfamily CATH Status
5nvvA00 10 Dec, 2017 3.10.20.90 Assigned
5nvvB00 10 Dec, 2017 3.30.710.10 Assigned
5nvvC01 10 Dec, 2017 2.60.40.780 Assigned
5nvvC02 10 Dec, 2017 1.10.750.10 Assigned
5nvvD00 10 Dec, 2017 3.10.20.90 Assigned
5nvvE00 10 Dec, 2017 3.30.710.10 Assigned
5nvvF01 10 Dec, 2017 2.60.40.780 Assigned
5nvvF02 10 Dec, 2017 1.10.750.10 Assigned
5nvvG00 10 Dec, 2017 3.10.20.90 Assigned
5nvvH00 10 Dec, 2017 3.30.710.10 Assigned
5nvvI01 10 Dec, 2017 2.60.40.780 Assigned
5nvvI02 10 Dec, 2017 1.10.750.10 Assigned
5nvvJ00 10 Dec, 2017 3.10.20.90 Assigned
5nvvK00 10 Dec, 2017 3.30.710.10 Assigned
5nvvL01 10 Dec, 2017 2.60.40.780 Assigned
5nvvL02 10 Dec, 2017 1.10.750.10 Assigned

UniProtKB Entries (12)

Accession Gene ID Taxon Description
P40337 VHL_HUMAN Homo sapiens von Hippel-Lindau disease tumor suppressor
Q15369 ELOC_HUMAN Homo sapiens Elongin-C
Q15369 ELOC_HUMAN Homo sapiens Elongin-C
Q15369 ELOC_HUMAN Homo sapiens Elongin-C
Q15370 ELOB_HUMAN Homo sapiens Elongin-B
Q15370 ELOB_HUMAN Homo sapiens Elongin-B
Q15370 ELOB_HUMAN Homo sapiens Elongin-B
P40337 VHL_HUMAN Homo sapiens von Hippel-Lindau disease tumor suppressor
P40337 VHL_HUMAN Homo sapiens von Hippel-Lindau disease tumor suppressor
Q15369 ELOC_HUMAN Homo sapiens Elongin-C
P40337 VHL_HUMAN Homo sapiens von Hippel-Lindau disease tumor suppressor
Q15370 ELOB_HUMAN Homo sapiens Elongin-B