PDB Information

PDB5M5E
MethodX-RAY DIFFRACTION
Host OrganismHomo sapiens
Gene SourceHomo sapiens
Primary Citation
Cergutuzumab amunaleukin (CEA-IL2v), a CEA-targeted IL-2 variant-based immunocytokine for combination cancer immunotherapy: Overcoming limitations of aldesleukin and conventional IL-2-based immunocytokines.
Klein, C., Waldhauer, I., Nicolini, V.G., Freimoser-Grundschober, A., Nayak, T., Vugts, D.J., Dunn, C., Bolijn, M., Benz, J., Stihle, M., Lang, S., Roemmele, M., Hofer, T., van Puijenbroek, E., Wittig, D., Moser, S., Ast, O., Brunker, P., Gorr, I.H., Neumann, S., de Vera Mudry, M.C., Hinton, H., Crameri, F., Saro, J., Evers, S., Gerdes, C., Bacac, M., van Dongen, G., Moessner, E., Umana, P.
Oncoimmunology
HeaderImmune System
Released2016-10-21
Resolution2.300
CATH Insert Date14 May, 2017

PDB Images (9)

PDB Prints

PDB Chains (3)

Chain ID Date inserted into CATH CATH Status
B 15 May, 2017 Chopped
C 15 May, 2017 Chopped
D 15 May, 2017 Chopped

CATH Domains (5)

Domain ID Date inserted into CATH Superfamily CATH Status
5m5eB01 06 Nov, 2017 2.60.40.10 Assigned
5m5eB02 06 Nov, 2017 2.60.40.10 Assigned
5m5eC01 06 Nov, 2017 2.60.40.10 Assigned
5m5eC02 06 Nov, 2017 2.60.40.10 Assigned
5m5eD00 06 Nov, 2017 1.20.1250.10 Assigned

UniProtKB Entries (3)

Accession Gene ID Taxon Description
P31785 IL2RG_HUMAN Homo sapiens Cytokine receptor common subunit gamma
P60568 IL2_HUMAN Homo sapiens Interleukin-2
P14784 IL2RB_HUMAN Homo sapiens Interleukin-2 receptor subunit beta