PDB 5lf6

PDB Links
Overview

PDB Information

PDB	5LF6
Method	X-RAY DIFFRACTION
Host Organism
Gene Source
Primary Citation	The inhibition mechanism of human 20S proteasomes enables next-generation inhibitor design. Schrader, J., Henneberg, F., Mata, R.A., Tittmann, K., Schneider, T.R., Stark, H., Bourenkov, G., Chari, A. Science
Header	Hydrolase
Released	2016-06-30
Resolution	2.070
CATH Insert Date	04 Sep, 2016

PDB Images (59)

5lf6

PDB 5lf6

5lf6a

PDB Chain 5lf6a

5lf6A

PDB Chain 5lf6A

5lf6b

PDB Chain 5lf6b

5lf6B

PDB Chain 5lf6B

5lf6c

PDB Chain 5lf6c

5lf6C

PDB Chain 5lf6C

5lf6d

PDB Chain 5lf6d

5lf6D

PDB Chain 5lf6D

5lf6E

PDB Chain 5lf6E

5lf6F

PDB Chain 5lf6F

5lf6G

PDB Chain 5lf6G

5lf6H

PDB Chain 5lf6H

5lf6I

PDB Chain 5lf6I

5lf6J

PDB Chain 5lf6J

5lf6K

PDB Chain 5lf6K

5lf6L

PDB Chain 5lf6L

5lf6M

PDB Chain 5lf6M

5lf6N

PDB Chain 5lf6N

5lf6O

PDB Chain 5lf6O

5lf6P

PDB Chain 5lf6P

5lf6Q

PDB Chain 5lf6Q

5lf6R

PDB Chain 5lf6R

5lf6S

PDB Chain 5lf6S

5lf6T

PDB Chain 5lf6T

5lf6U

PDB Chain 5lf6U

5lf6V

PDB Chain 5lf6V

5lf6W

PDB Chain 5lf6W

5lf6X

PDB Chain 5lf6X

5lf6Y

PDB Chain 5lf6Y

5lf6Z

PDB Chain 5lf6Z

5lf6a00

CATH Domain 5lf6a00

5lf6A00

CATH Domain 5lf6A00

5lf6b00

CATH Domain 5lf6b00

5lf6B00

CATH Domain 5lf6B00

5lf6C00

CATH Domain 5lf6C00

5lf6D00

CATH Domain 5lf6D00

5lf6E00

CATH Domain 5lf6E00

5lf6F00

CATH Domain 5lf6F00

5lf6G00

CATH Domain 5lf6G00

5lf6H00

CATH Domain 5lf6H00

5lf6I00

CATH Domain 5lf6I00

5lf6J00

CATH Domain 5lf6J00

5lf6K00

CATH Domain 5lf6K00

5lf6L00

CATH Domain 5lf6L00

5lf6M00

CATH Domain 5lf6M00

5lf6N00

CATH Domain 5lf6N00

5lf6O00

CATH Domain 5lf6O00

5lf6P00

CATH Domain 5lf6P00

5lf6Q00

CATH Domain 5lf6Q00

5lf6R00

CATH Domain 5lf6R00

5lf6S00

CATH Domain 5lf6S00

5lf6T00

CATH Domain 5lf6T00

5lf6U00

CATH Domain 5lf6U00

5lf6V00

CATH Domain 5lf6V00

5lf6W00

CATH Domain 5lf6W00

5lf6X00

CATH Domain 5lf6X00

5lf6Y00

CATH Domain 5lf6Y00

5lf6Z00

CATH Domain 5lf6Z00

PDB Prints

PDB Chains (30)

Chain ID	Date inserted into CATH	CATH Status
a	05 Sep, 2016	Chopped
A	05 Sep, 2016	Chopped
b	05 Sep, 2016	Chopped
B	05 Sep, 2016	Chopped
c	05 Sep, 2016	Rejected
C	05 Sep, 2016	Chopped
d	05 Sep, 2016	Rejected
D	05 Sep, 2016	Chopped
E	05 Sep, 2016	Chopped
F	05 Sep, 2016	Chopped
G	05 Sep, 2016	Chopped
H	05 Sep, 2016	Chopped
I	05 Sep, 2016	Chopped
J	05 Sep, 2016	Chopped
K	05 Sep, 2016	Chopped
L	05 Sep, 2016	Chopped
M	05 Sep, 2016	Chopped
N	05 Sep, 2016	Chopped
O	05 Sep, 2016	Chopped
P	05 Sep, 2016	Chopped
Q	05 Sep, 2016	Chopped
R	05 Sep, 2016	Chopped
S	05 Sep, 2016	Chopped
T	05 Sep, 2016	Chopped
U	05 Sep, 2016	Chopped
V	05 Sep, 2016	Chopped
W	05 Sep, 2016	Chopped
X	05 Sep, 2016	Chopped
Y	05 Sep, 2016	Chopped
Z	05 Sep, 2016	Chopped

CATH Domains (28)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
5lf6a00	09 Sep, 2016	3.60.20.10	Assigned
5lf6A00	09 Sep, 2016	3.60.20.10	Assigned
5lf6b00	20 Oct, 2016	3.60.20.10	Assigned
5lf6B00	09 Sep, 2016	3.60.20.10	Assigned
5lf6C00	09 Sep, 2016	3.60.20.10	Assigned
5lf6D00	09 Sep, 2016	3.60.20.10	Assigned
5lf6E00	09 Sep, 2016	3.60.20.10	Assigned
5lf6F00	09 Sep, 2016	3.60.20.10	Assigned
5lf6G00	09 Sep, 2016	3.60.20.10	Assigned
5lf6H00	09 Sep, 2016	3.60.20.10	Assigned
5lf6I00	09 Sep, 2016	3.60.20.10	Assigned
5lf6J00	09 Sep, 2016	3.60.20.10	Assigned
5lf6K00	09 Sep, 2016	3.60.20.10	Assigned
5lf6L00	09 Sep, 2016	3.60.20.10	Assigned
5lf6M00	09 Sep, 2016	3.60.20.10	Assigned
5lf6N00	20 Oct, 2016	3.60.20.10	Assigned
5lf6O00	09 Sep, 2016	3.60.20.10	Assigned
5lf6P00	09 Sep, 2016	3.60.20.10	Assigned
5lf6Q00	09 Sep, 2016	3.60.20.10	Assigned
5lf6R00	09 Sep, 2016	3.60.20.10	Assigned
5lf6S00	09 Sep, 2016	3.60.20.10	Assigned
5lf6T00	09 Sep, 2016	3.60.20.10	Assigned
5lf6U00	09 Sep, 2016	3.60.20.10	Assigned
5lf6V00	09 Sep, 2016	3.60.20.10	Assigned
5lf6W00	09 Sep, 2016	3.60.20.10	Assigned
5lf6X00	09 Sep, 2016	3.60.20.10	Assigned
5lf6Y00	09 Sep, 2016	3.60.20.10	Assigned
5lf6Z00	09 Sep, 2016	3.60.20.10	Assigned

UniProtKB Entries (28)

Accession	Gene ID	Taxon	Description
P49720	PSB3_HUMAN	Homo sapiens	Proteasome subunit beta type-3
P28066	PSA5_HUMAN	Homo sapiens	Proteasome subunit alpha type-5
P28072	PSB6_HUMAN	Homo sapiens	Proteasome subunit beta type-6
P28072	PSB6_HUMAN	Homo sapiens	Proteasome subunit beta type-6
O14818	PSA7_HUMAN	Homo sapiens	Proteasome subunit alpha type-7
O14818	PSA7_HUMAN	Homo sapiens	Proteasome subunit alpha type-7
Q99436	PSB7_HUMAN	Homo sapiens	Proteasome subunit beta type-7
P28074	PSB5_HUMAN	Homo sapiens	Proteasome subunit beta type-5
P28070	PSB4_HUMAN	Homo sapiens	Proteasome subunit beta type-4
P25787	PSA2_HUMAN	Homo sapiens	Proteasome subunit alpha type-2
P25789	PSA4_HUMAN	Homo sapiens	Proteasome subunit alpha type-4
P25788	PSA3_HUMAN	Homo sapiens	Proteasome subunit alpha type-3
P60900	PSA6_HUMAN	Homo sapiens	Proteasome subunit alpha type-6
P28070	PSB4_HUMAN	Homo sapiens	Proteasome subunit beta type-4
P25789	PSA4_HUMAN	Homo sapiens	Proteasome subunit alpha type-4
Q99436	PSB7_HUMAN	Homo sapiens	Proteasome subunit beta type-7
P25786	PSA1_HUMAN	Homo sapiens	Proteasome subunit alpha type-1
P49720	PSB3_HUMAN	Homo sapiens	Proteasome subunit beta type-3
P28074	PSB5_HUMAN	Homo sapiens	Proteasome subunit beta type-5
P28066	PSA5_HUMAN	Homo sapiens	Proteasome subunit alpha type-5
P20618	PSB1_HUMAN	Homo sapiens	Proteasome subunit beta type-1
P20618	PSB1_HUMAN	Homo sapiens	Proteasome subunit beta type-1
P49721	PSB2_HUMAN	Homo sapiens	Proteasome subunit beta type-2
P49721	PSB2_HUMAN	Homo sapiens	Proteasome subunit beta type-2
P25786	PSA1_HUMAN	Homo sapiens	Proteasome subunit alpha type-1
P60900	PSA6_HUMAN	Homo sapiens	Proteasome subunit alpha type-6
P25787	PSA2_HUMAN	Homo sapiens	Proteasome subunit alpha type-2
P25788	PSA3_HUMAN	Homo sapiens	Proteasome subunit alpha type-3